Effects of exercise and L-arginine intake on inflammation in aorta of high-fat diet induced obese rats
| Autor: | Eun Hee Jin, Sok Park, Jun Seok Son, Hee-jae Kim, Jin Lee |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Arginine Inflammation arginine 030204 cardiovascular system & hematology Superoxide dismutase 03 medical and health sciences 0302 clinical medicine Arginine intake Internal medicine medicine.artery medicine Exercise Aorta biology business.industry High fat diet aorta 030104 developmental biology Endocrinology inflammation biology.protein Original Article medicine.symptom business |
| Zdroj: | Journal of Exercise Nutrition & Biochemistry |
| ISSN: | 2233-6834 |
| Popis: | [Purpose] In the present study, we investigated the effect of exercise and arginine on the inflammatory makers and Cu-Mn superoxide dismutase (SOD) expression in the aortas of high-fat-induced obese rats. [Methods] Fifty 6-month-old male Sprague-Dawley rats were randomly assigned as follows: HF-Con: high-fat diet, HF-Ex: high-fat diet and exercise, HF-Ex+A: high-fat diet and combined exercise and arginine, HF-A: high-fat diet and arginine. The high-fat diet was fed for 12 weeks following 1 week of environmental adaptation with mixed solid chow. The rats performed treadmill exercise 6 times per week for 12 weeks at20 m/min for 60 min. L-argininewas mixed with saline and orally administered at 150 mg/kg once a day. Expressions of inflammatory markers (including NF- κB, TNF-α, COX-2) and SOD were evaluated using western blotting. [Results] NF-κB expression decreased significantly (p |
| Databáze: | OpenAIRE |
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