A trial comparing continuous positive airway pressure (CPAP) devices in preterm infants

Autor:	Michael R. Stenger, Thomas N. Hansen, C Peter Richardson, Mohannad Moallem, Stephen E. Welty, Randy R. Miller, Laura Marzec, Larissa Stanberry, Lindsey J. Beer, Crystal M Alfred, Charles V. Smith, Christopher R A Howard, Jennifer N. Cooper, Brian K. Rivera, Molly K. Ball, Jennifer L. Notestine, Apurwa Naik, Carl H. Backes, Jane M. Lamp, Noah H. Hillman, John A.F. Zupancic
Rok vydání:	2020
Předmět:	medicine.medical_specialty medicine.medical_treatment Gestational Age Subgroup analysis Article Treatment failure 03 medical and health sciences 0302 clinical medicine Pregnancy Intensive Care Units Neonatal 030225 pediatrics Humans Medicine 030212 general & internal medicine Continuous positive airway pressure Adverse effect Respiratory Distress Syndrome Newborn Continuous Positive Airway Pressure business.industry Obstetrics Infant Newborn Absolute risk reduction Infant Obstetrics and Gynecology Gestational age Paediatrics Translational research Respiratory support nervous system diseases respiratory tract diseases Pediatrics Perinatology and Child Health Gestation Female business therapeutics Infant Premature
Zdroj:	Journal of Perinatology
ISSN:	1476-5543 0743-8346
Popis:	Objective To test the hypothesis that infants born Study design Randomized trial (3/2017-01/2019) at 5 NICUs. The primary outcome was CPAP failure; subgroup analyses (gestational age, receipt antenatal corticosteroids) were performed. Results A total of 232 infants were randomized. Infants in the Seattle-PAP and FP-CPAP groups had mean gestational ages of 27.0 and 27.2 weeks, respectively. We observed no differences in rates of treatment failure between Seattle-PAP (40/112, 35.7%) and FP-CPAP (38/120, 31.7%; risk difference, 4.1%; 95% CI, −8.1–16.2; P = 0.51). Subgroup analysis indicated no differences in rates of CPAP failure. We observed no differences between the two groups in frequencies of adverse events or duration of respiratory support. Conclusions Among infants born
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5efed21878d7b1e261a90cec68752a32 https://doi.org/10.1038/s41372-020-0690-5 Zobrazit plný text záznamu Full text from SpringerLink