Identification of infectious entities in idiopathic orbital inflammation biopsies
| Autor: | Jolanda D.F. de Groot-Mijnes, Rachel Kalmann, Dion Paridaens, Ward R Bijlsma, Maarten Philip Mourits, Jojanneke Dekkers, Roel Kloos |
|---|---|
| Přispěvatelé: | AII - Amsterdam institute for Infection and Immunity, Ophthalmology |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Epstein-Barr Virus Infections Herpesvirus 4 Human Adolescent Biopsy Herpesvirus 6 Human Eye Infections Viral Roseolovirus Infections Disease Real-Time Polymerase Chain Reaction Parvoviridae Infections Cellular and Molecular Neuroscience Young Adult Orbital Pseudotumor Parvovirus B19 Human Medicine Humans Prospective Studies Young adult Prospective cohort study Aged Diplopia Aged 80 and over medicine.diagnostic_test business.industry Eye infection Middle Aged Idiopathic orbital inflammation medicine.disease Dermatology Sensory Systems Ophthalmology Upper respiratory tract infection DNA Viral Female medicine.symptom business |
| Zdroj: | British journal of ophthalmology, 97(5), 664-665. BMJ Publishing Group |
| ISSN: | 0007-1161 |
| Popis: | Idiopathic orbital inflammation (IOI) is a poorly understood disease that can cause symptoms of pain, proptosis and diplopia. The condition is considered of non-infectious origin and a diagnosis is only made after exclusion of a neoplasm, primary infection and systemic disorders. However, a recent history of upper respiratory tract infection prior to development of IOI is not uncommon.1 It has been postulated that IOI is caused by an auto-immune response that develops after an infectious trigger.2 We investigated whether IOI may have an infectious origin by using molecular techniques to identify genetic material of a panel of viruses and bacteria in tissue biopsies of patients with IOI and controls. After ethical review board approval, 48 orbital biopsy specimens were collected at orbital clinics in Amsterdam, Maastricht, Rotterdam … |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|