Indomethacin attenuates hyperthermia produced by anterior coronal lateral hypothalamic knife cuts
| Autor: | Carlos V. Grijalva, Vinuta Rau |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Hyperthermia medicine.medical_specialty Time Factors Fever Lateral hypothalamus Indomethacin Prostaglandin Body Temperature Rats Sprague-Dawley chemistry.chemical_compound Feeding behavior Internal medicine Brown adipose tissue medicine Animals Knife cuts General Neuroscience Anti-Inflammatory Agents Non-Steroidal medicine.disease Rats Preoptic area medicine.anatomical_structure Endocrinology chemistry Brain Injuries Hypothalamic Area Lateral Coronal plane |
| Zdroj: | Brain Research Bulletin. 64:53-58 |
| ISSN: | 0361-9230 |
| DOI: | 10.1016/j.brainresbull.2004.05.004 |
| Popis: | Electrolytic lesions of the lateral hypothalamus (LH) and coronal knife cuts of fibers anterior to the LH produce an elevation in core body temperature, or hyperthermia. Prostaglandin has been shown to mediate hyperthermia produced by electrolytic LH lesions. The present study characterizes the time course and the role of prostaglandin in mediating knife-cut-induced hyperthermia. Results show that the prostaglandin synthesis inhibitor indomethacin significantly attenuates hyperthermia produced by the knife cuts, suggesting that prostaglandin is involved in mediating this temperature increase. A disruption of axonal fibers that project from the LH to the preoptic area is postulated to be responsible for the temperature increase. There was no effect of knife cuts on food intake and body weight loss, which were also measured, suggesting that this fiber system is not involved in feeding behavior. |
| Databáze: | OpenAIRE |
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