Resistance exercise-induced muscle fatigue is not accompanied by increased phosphorylation of ryanodine receptor 1 at serine 2843
| Autor: | Markus de Marées, Linnea Nirenberg, Sebastian Gehlert, Patrick Ritter, Gerrit Friederichs, Jan Eisenbraun, Daniel Jacko, Käthe Bersiner, Wilhelm Bloch |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Muscle Physiology Physiology Biopsy lcsh:Medicine Isometric exercise Biochemistry Material Fatigue Muscle hypertrophy Materials Physics Serine Medicine and Health Sciences Medicine Public and Occupational Health Phosphorylation Post-Translational Modification lcsh:Science Musculoskeletal System Multidisciplinary Ryanodine receptor Physics Muscles Classical Mechanics Immunohistochemistry Quadriceps femoris muscle Sports Science Muscle Fatigue Physical Sciences Strength Training Legs medicine.symptom Anatomy Muscle contraction Research Article Muscle Contraction Adult medicine.medical_specialty Strength training Materials Science Surgical and Invasive Medical Procedures Contractility 03 medical and health sciences Young Adult Motion Internal medicine Humans Sports and Exercise Medicine Exercise Damage Mechanics Muscle fatigue business.industry lcsh:R Limbs (Anatomy) Biology and Life Sciences Proteins Resistance Training Ryanodine Receptor Calcium Release Channel Physical Activity 030104 developmental biology Endocrinology Skeletal Muscles Torque Physical Fitness lcsh:Q business |
| Zdroj: | PLoS ONE PLoS ONE, Vol 13, Iss 6, p e0199307 (2018) |
| ISSN: | 1932-6203 |
| Popis: | Skeletal muscle fatigue has been shown to be associated with hyperphosphorylation of the ryanodine receptor 1 at serine 2843 (pRyR1Ser2843), due to chronic overloading exercise. We investigated whether pRyR1Ser2843, is a mechanism relevant for muscle fatigue also under acute, in contrast to chronic, muscle loading. 24 male subjects (age: 24,8±3,8; height: 182,8±7,2 cm; weight: 82,5±9,9 kg) were evenly (n = 6) assigned to the following four different resistance exercise (RE) groups: hypertrophy- (HYP), strength endurance- (SE), maximum power- (MAX) at the subjects' 10, 25 and 3 repetition maximum, respectively, and low intensity (LI) RE with 70% of the 10 repetition maximum. Each group completed three different RE volumes (1 set, 5, and 10 sets). Muscle biopsies from the vastus lateralis were taken before and after exercise, analyzed for pRyR1Ser2843 and examined for association with RE-induced muscle fatigue which was determined as reduction in maximum isometric force (isoFmax) in the quadriceps femoris muscle also before and after exercise.The degree of RE-induced muscle fatigue was specific in terms of set volume as well as of RE mode. isoFmax was not reduced in any group after one set of RE. Five sets led to a significant reduction of isoFmax in HYP and SE but not in LI and MAX (p |
| Databáze: | OpenAIRE |
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