Formyl Group Activation of a Bromopyrrole Ester in Suzuki Cross-Coupling Reactions: Application to a Formal Synthesis of Polycitone A and B and Polycitrin A

Autor:	Andrew Harrison, Kristin Lescalleet, Michael Kimmel, John Sobieski, Emily J. Kluball, Nakul Telang, Jon Patteson, John T. Gupton, Michael Wormald, Will Curry, Thomas Perry, Megan E. Hoerrner
Jazyk:	angličtina
Rok vydání:	2014
Předmět:	Formal synthesis chemistry.chemical_compound Polycitone B Chemistry Block (telecommunications) Organic Chemistry Drug Discovery Formyl group Biochemistry Combinatorial chemistry Coupling reaction Article Pyrrole
Popis:	A new pyrrole building block is described, which allows for the regiospecific synthesis of 2,3,5-trisubstituted pyrroles and 2,3,4,5-tetrasubstituted pyrroles. Optimization studies are presented for the preparation of the pyrrole building block along with the evaluation of various cross-coupling conditions and cross-coupling agents. A short, formal synthesis of the natural products Polycitone A, Polycitone B, and Polycitrin A from the pyrrole building block is also described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eefe97d3294fbd48829462a1e31c0d7 https://europepmc.org/articles/PMC4004070/ Zobrazit plný text záznamu