Hypokalaemic paralysis and metabolic alkalosis in a patient with Sjögren syndrome: a case report and literature review
| Autor: | Shehan Perera, Aruna Gunapala, Rasika Ranaweerage |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
030232 urology & nephrology Metabolic alkalosis Case Report Hypokalemia Spironolactone Gastroenterology Hypocalciuria Autoimmune thyroiditis Diagnosis Differential 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Internal medicine medicine Paralysis Humans Hypokalaemia 030203 arthritis & rheumatology Acquired Gitelman syndrome business.industry Lower limb muscle weakness Gitelman syndrome medicine.disease Sjögren syndrome Diseases of the genitourinary system. Urology Sjogren's Syndrome chemistry Nephrology Dietary Supplements Potassium RC870-923 medicine.symptom Differential diagnosis business Gitelman Syndrome |
| Zdroj: | BMC Nephrology BMC Nephrology, Vol 22, Iss 1, Pp 1-4 (2021) |
| ISSN: | 1471-2369 |
| Popis: | Background Acquired Gitelman syndrome is a very rare disorder reported in association with autoimmune disorders, mostly Sjögren syndrome. It is characterized by the presence of hypokalaemic metabolic alkalosis, hypocalciuria, hypomagnesaemia and hyper-reninaemia, in the absence of typical genetic mutations associated with inherited Gitelman syndrome. Case presentation A 20 year old woman who was previously diagnosed with primary Sjögren syndrome and autoimmune thyroiditis presented with two week history of lower limb weakness and salt craving. Examination revealed upper limb and lower limb muscle weakness with muscle power of 3/5 on MRC scale and diminished deep tendon reflexes. On evaluation, she had hypokalaemia with high trans-tubular potassium gradient, metabolic alkalosis and hypocalciuria, features suggestive of Gitelman syndrome. New onset hypokalaemic alkalosis in a previously normokalaemic patient with Sjögren syndrome strongly favored a diagnosis of acquired Gitelman syndrome. Daily potassium supplementation and spironolactone resulted in complete clinical recovery. Conclusions Acquired Gitelman syndrome associated with Sjögren syndrome is rare. It should be considered as a differential diagnosis during evaluation of acute paralysis and hypokalaemic metabolic alkalosis in patients with autoimmune disorders, especially Sjögren syndrome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink