Single visit rabies pre-exposure priming induces a robust anamnestic antibody response after simulated post-exposure vaccination: results of a dose-finding study
| Autor: | Emile F.F. Jonker, Leonardus G Visser |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Adolescent Injections Intradermal Single visit Office Visits Rabies 030231 tropical medicine Priming (immunology) medicine.disease_cause Antibodies Viral Injections Intramuscular memory 03 medical and health sciences Young Adult 0302 clinical medicine Rabies vaccine medicine Humans 030212 general & internal medicine intradermal priming Aged Travel biology Dose-Response Relationship Drug business.industry Rabies virus General Medicine Middle Aged medicine.disease vaccination pre-exposure Vaccination Titer Treatment Outcome Rabies Vaccines Immunology Antibody Formation biology.protein Female Antibody business Post-Exposure Prophylaxis post-exposure medicine.drug |
| Zdroj: | Journal of Travel Medicine, 24(5) |
| Popis: | Background The current standard 3-dose intramuscular rabies PrEP schedule suffers from a number of disadvantages that severely limit accessibility and availability. The cost of is often prohibitive, it requires 3 visits to the clinic, and there are regular vaccine shortages. Methods Volunteers ( N = 30) were randomly assigned to 4 study arms: 1 standard dose intramuscular (IM) dose of PVRV (purified Vero cell rabies vaccine, Verorab), and 1/5th, 2/5th or 3/5th- fractional intradermal (ID) dose of PVRV in a single visit. All subjects received a simulated rabies post-exposure prophylaxis (D0, D3) 1 year later. Rabies virus neutralizing antibodies (RVNA) were determined by virus neutralization microtest (FAVN) on D0, D7, D28, Y1 and Y1 + D7. Results 28 out of 30 subjects (93%) seroconverted 1 month after primary vaccination; 1 subject in the 1-dose IM arm and 1 in the 1/5th-fractional dose ID arm did not. After 1 year, 22 out of 30 subjects (73%) no longer had RVNA above 0.5 IU/ml, with no discernible difference between study groups. After 1 year, all 30 subjects mounted a booster response within 7 days after simulated PEP, with the highest titers found in the single dose IM group ( P |
| Databáze: | OpenAIRE |
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