Results of a two year chronic toxicity study with hexachlorobutadiene in rats
| Autor: | D.A. Dittenber, R.J. Kociba, J. J. Ballard, Charles G Humiston, D. G. Keyes, C.E. Wade, J.F. Quast, G. C. Jersey, B.A. Schwetz |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Adenoma
Male Coproporphyrins medicine.medical_specialty Physiology Adenocarcinoma Kidney chemistry.chemical_compound Neoplasms Butadienes Animals Ingestion Medicine Chronic toxicity business.industry Body Weight Public Health Environmental and Occupational Health Kidney pathology Organ Size Kidney Neoplasms Diet Rats Surgery Hexachlorobutadiene Kidney Tubules chemistry Toxicity Female business Kidney tubules |
| Zdroj: | American Industrial Hygiene Association Journal. 38:589-602 |
| ISSN: | 0002-8894 |
| DOI: | 10.1080/00028897708984403 |
| Popis: | Lifetime ingestion by rats of 0.2 mg/kg/day of hexachlorobutadiene caused no discernible ill effects. Slight degrees of primarily renal toxicity occurred with 2 mg/kg/day; 20 mg/kg/day caused multiple toxic effects, including renal tubular neoplasms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|