Biomarkers of adiposity are elevated in preterm very-low-birth-weight infants at 1, 2, and 3 y of age
| Autor: | Andrea F. Duncan, Charles R. Rosenfeld, Roy J. Heyne, Joshua A. Frankfurt |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Leptin
Male medicine.medical_specialty Adipokine Blood Pressure Gestational Age 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Weight Gain 03 medical and health sciences Child Development Sex Factors 0302 clinical medicine Skin fold Risk Factors Internal medicine medicine Humans Infant Very Low Birth Weight Resistin Adiposity Metabolic Syndrome business.industry Age Factors Infant Newborn Infant Gestational age medicine.disease Skinfold Thickness Low birth weight Cross-Sectional Studies Endocrinology Child Preschool Pediatrics Perinatology and Child Health Female Adiponectin Waist Circumference Metabolic syndrome medicine.symptom business Weight gain Biomarkers Infant Premature |
| Zdroj: | Pediatric Research. 81:780-786 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1038/pr.2017.11 |
| Popis: | Preterm, very-low-birth-weight (PT-VLBW) neonates are at-risk for metabolic syndrome later in life. At 1–3 y, they exhibit excessive weight-for-length z-scores (Wt-LZ) and elevated systolic blood pressures (SBP). Serum adipokines are biomarkers of adiposity, but expression in PT-VLBW infants is unclear. We examined the correlation between serum adipokine levels, anthropometric measures and SBP in PT-VLBW neonates at follow-up. This was a cross-sectional cohort study of PT-VLBW infants at 1, 2, and 3 y of age (40/cohort). We measured SBP, abdominal circumference (AC) and anthropometrics; calculated age/gender-specific z-scores for Wt, L, Wt-L and subscapular skin fold (SSZ), and measured serum adipokines. Serum leptin was unaffected by chronologic age and gender, but was positively correlated with weight, Wt-LZ, AC, and SSZ at 1 and 3 y (P males, suggesting leptin resistance may occur in early infancy. |
| Databáze: | OpenAIRE |
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