Increased expression of matrix metalloproteinase-9 associated with gastric ulcer recurrence

Autor: Sen-Lin Li, Jia-Ping Xie, Xiao-Yan Ren, Qiu-Hua Rong, Jing-Run Zhao, Qing-Zhu Ma
Rok vydání: 2013
Předmět:
Male
Pathology
Time Factors
Biopsy
Gastroenterology
Endoscopy
Gastrointestinal
Tissue Culture Techniques
Recurrence
Risk Factors
Odds Ratio
Antrum
medicine.diagnostic_test
biology
General Medicine
Middle Aged
Anti-Bacterial Agents
Up-Regulation
medicine.anatomical_structure
Treatment Outcome
Matrix Metalloproteinase 9
Gastritis
Drug Therapy
Combination
Female
medicine.symptom
Adult
medicine.medical_specialty
Brief Article
Helicobacter Infections
Young Adult
Internal medicine
medicine
Gastric mucosa
Humans
Stomach Ulcer
Aged
Chi-Square Distribution
Tissue Inhibitor of Metalloproteinase-1
Helicobacter pylori
business.industry
Proton Pump Inhibitors
Odds ratio
Tissue inhibitor of metalloproteinase
biology.organism_classification
digestive system diseases
Endoscopy
Logistic Models
Gastric Mucosa
Chronic Disease
Multivariate Analysis
business
Biomarkers
Zdroj: World journal of gastroenterology. 19(28)
ISSN: 2219-2840
Popis: AIM: To compare matrix metalloproteinase (MMP)-9 and tissue inhibitor of metalloproteinase (TIMP)-1 in gastric ulcer (GU) and chronic superficial gastritis (CSG). METHODS: This study enrolled 63 patients with GU and 25 patients with CSG. During upper gastroduodenal endoscopy, we took samples of gastric mucosa from the antrum and ulcer site from patients with GU, and samples of antral mucosa from patients with CSG. Mucosal biopsy tissues were cultured for 24 h, and the culture supernatant was measured for levels of MMP-9 and TIMP-1. After receiving eradication therapy for Helicobacter pylori (H. pylori) and 8 wk proton-pump inhibitor therapy for GU, follow-up endoscopy examination was performed after 6 mo and whenever severe symptoms occurred. RESULTS: Levels of MMP-9 and TIMP-1 at the ulcer site or in the antrum were significantly higher in GU than CSG patients. MMP-9 levels at the ulcer site were significantly higher than in the antrum in GU patients, and had a significantly positive correlation with TIMP-1. MMP-9 levels were significantly higher in H. pylori-positive than H. pylori-negative GU and CSG patients. Levels of MMP-9 or TIMP-1 at the ulcer site were associated with the histological severity of activity and inflammation. About 57 GU patients were followed up, and seven had GU recurrence. H. pyloriinfection and MMP-9 levels were risk factors for the recurrence of GU adjusted for age and sex by multiple logistic regression analysis. CONCLUSION: MMP-9 may perform an important function in gastric ulcer formation and recurrence.
Databáze: OpenAIRE
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