The role of serotonin in respiratory function and dysfunction

Autor: Clément Menuet, Hari H. Subramanian, Nicolas Voituron, Gérard Hilaire, Mathias Dutschmann, Ronaldo M. Ichiyama
Přispěvatelé: Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Physiology
Developmental Disabilities
MESH: Neurons
0302 clinical medicine
MESH: Up-Regulation
Respiratory function
MESH: Animals
MESH: Homoserine
Neurons
0303 health sciences
Respiration
General Neuroscience
Neurodegeneration
Brain
MESH: Respiration Disorders
MESH: Epithelial Cells
MESH: Pseudomonas aeruginosa
Brainstem
Neurotrophin
MESH: Cells
Cultured
Pulmonary and Respiratory Medicine
Serotonin
MESH: Receptors
Serotonin
Respiratory rate
Biology
Serotonergic
MESH: Nervous System Diseases
Article
03 medical and health sciences
MESH: Brain
MESH: Gene Expression Profiling
medicine
Animals
Humans
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Biochemistry [q-bio.BM]
MESH: Mice
030304 developmental biology
MESH: Respiration
MESH: Humans
MESH: Cytoplasm
MESH: Time Factors
Respiration Disorders
medicine.disease
Mental illness
MESH: Microarray Analysis
MESH: Developmental Disabilities
MESH: Metabolic Networks and Pathways
Receptors
Serotonin
biology.protein
MESH: Biological Transport
Active
MESH: 4-Butyrolactone
MESH: Serotonin
Nervous System Diseases
Neuroscience
030217 neurology & neurosurgery
Zdroj: Microbes and Infection
Microbes and Infection, 2010, 174 (1-2), pp.76-88. ⟨10.1016/j.resp.2010.08.017⟩
Microbes and Infection, Elsevier, 2010, 174 (1-2), pp.76-88. ⟨10.1016/j.resp.2010.08.017⟩
ISSN: 1286-4579
DOI: 10.1016/j.resp.2010.08.017⟩
Popis: International audience; Serotonin (5-HT) is a neuromodulator-transmitter influencing global brain function. Past and present findings illustrate a prominent role for 5-HT in the modulation of ponto-medullary autonomic circuits. 5-HT is also involved in the control of neurotrophic processes during pre- and postnatal development of neural circuits. The functional implications of 5-HT are particularly illustrated in the alterations to the serotonergic system, as seen in a wide range of neurological disorders. This article reviews the role of 5-HT in the development and control of respiratory networks in the ponto-medullary brainstem. The review further examines the role of 5-HT in breathing disorders occurring at different stages of life, in particular, the neonatal neurodevelopmental diseases such as Rett, sudden infant death and Prader-Willi syndromes, adult diseases such as sleep apnoea and mental illness linked to neurodegeneration.
Databáze: OpenAIRE
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