Plasma Bradykinin Levels and Urinary Kallikrein Excretion in Normal Renin Essential Hypertension*
| Autor: | Robert G. Dluhy, Gordon H. Williams, Rodica L. Emanuel, Thomas J. Moore, James H. Mersey, Patrick Y. Wong |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Posture Clinical Biochemistry Renal function Bradykinin Vasodilation urologic and male genital diseases Essential hypertension Biochemistry Excretion chemistry.chemical_compound Endocrinology Internal medicine Renin Renin–angiotensin system medicine Humans cardiovascular diseases Child Kidney urogenital system Sodium Biochemistry (medical) Kinin medicine.disease biological factors Diet medicine.anatomical_structure chemistry Hypertension Female Kallikreins circulatory and respiratory physiology |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 48:642-647 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-48-4-642 |
| Popis: | Previous studies have documented subnormal urinary kallikrein excretion in patients with essential hypertension. Since recent evidence suggests that renal kallikrein can contribute to the circulating kinin pool, it could be hypothesized that decreased activity of the kallikrein-kinin vasodilatory system may contribute to the hypertensive process in these patients by decreasing systemic vasodilator activity. To test this possibility, urinary kallikrein excretion and plasma kinin levels were compared in 30 hypertensive and 21 normotensive subjects. Only subjects with essential hypertension and normal levels of PRA were included in this study; the hypertensive and normotensive groups were similar with regard to age, sex, and race distribution. Subjects were studied in balance on a diet containing 10 meq Na/100 meq K-day. PRA and kinin levels were measured by RIA and urinary kallikrein was measured by the αN-P-tosyl-Larginine-methyl ester esterase method. As in previous studies, it was found that mea... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|