Diagnostic meaning of blood p-cresol concentration in forensic autopsy cases
| Autor: | Masayuki Kashiwagi, Natsuki Ikematsu, Kenji Hara, Aya Matsusue, Brian Waters, Mio Takayama, Shin-ichi Kubo |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Pathology Time Factors Adolescent 030232 urology & nephrology Autopsy Urine Gastroenterology Body Mass Index Pathology and Forensic Medicine Excretion Cresols Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Tandem Mass Spectrometry Internal medicine parasitic diseases medicine Humans Aged Aged 80 and over Kidney Glomerulosclerosis Focal Segmental business.industry Coronary Stenosis Fasting Cresol Forensic Medicine Middle Aged Atherosclerosis Issues ethics and legal aspects 030104 developmental biology medicine.anatomical_structure chemistry Postmortem Changes Female p-Cresol business Forensic autopsy Biomarkers medicine.drug Artery |
| Zdroj: | Legal Medicine. 34:27-35 |
| ISSN: | 1344-6223 |
| Popis: | In some forensic autopsy cases there are high concentrations of p- cresol in the blood. In vivo, p- cresol is the only isomer yielded by intestinal bacteria and is excreted into urine. We investigated the diagnostic meaning of p- cresol in the blood of forensic autopsy cases. Blood samples from 110 autopsy cases within 48 h of the postmortem interval (PMI) and 10 healthy adults were examined. Blood with p- cresol-d 8 as an internal standard was analyzed using a GC–MS/MS method. Using acid and heat deproteinization, free (F) and conjugated (non-protein bound: C; protein bound: PC) p- cresol were individually analyzed. The p- cresol concentrations were 1.39 ± 0.86 µg/ml [mean ± SD] and 1.18 (0.19–18.80) µg/ml [median (range)] in healthy adults and autopsy cases, respectively. The p- cresol showed no significant relationship to age, sex, fasting duration, survival duration, or PMI. No significant differences were found between causes of death. Significantly higher levels of C p- cresol were found in cases with atherosclerosis in the basilar or renal arteries, or stenosis in the coronary artery. Significantly higher levels of p- cresol except F were found in cases with hyalinosis of the kidney. Cases with low BMI also showed significantly higher p- cresol concentrations. The 22 cases of abnormally high total p- cresol were investigated. It was considered that high concentrations of p- cresol could be an indicator of certain diseases and physical conditions that effect the production, absorption, metabolism, circulation, and excretion of p- cresol. Measuring the levels of p- cresol may provide valuable information about the antemortem physical conditions. |
| Databáze: | OpenAIRE |
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