Fungal Infection in Heart Transplant Recipients With Severe Sepsis: Single-Center Experience
| Autor: | Hsin-Yun Sun, Shu-Chien Huang, Yih-Sharng Chen, Hsi-Yu Yu, Shoei-Shen Wang, C.-I. Tsao, Nai-Hsin Chi, Shu-Hsun Chu, Shan-Chwen Chang, I.W. Wu, Nai-Kuan Chou, Wen-Je Ko |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Antifungal Agents Critical Care Multiple Organ Failure medicine.medical_treatment Sepsis Extracorporeal Membrane Oxygenation Intensive care medicine Humans Intensive care medicine Mycosis Retrospective Studies Heart transplantation Transplantation business.industry Nocardiosis Immunosuppression Middle Aged medicine.disease Survival Rate Mycoses Bacteremia Heart Transplantation Drug Therapy Combination Female Surgery business |
| Zdroj: | Transplantation Proceedings. 42:952-954 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/j.transproceed.2010.02.049 |
| Popis: | The objective of this study was to describe in heart transplant recipients severe sepsis due to fungal infection, which is associated with high mortality. This was a retrospective study including 366 patients who underwent heart transplantation from 1987 to 2009 in whom severe sepsis due to fungal infection developed, with multiple-organ failure. Sepsis was diagnosed on the basis of a positive culture for the infective agent, such as Cryptococcus, Aspergillus, Candida, or Nocardia, from an appropriate source such as blood, wound, or sputum. In 10 patients, severe sepsis due to fungal infection was treated temporally by reducing or sparing immunosuppression; 7 of these patients survived after intensive care. Only 1 patient required pulsed therapy because of an acute rejection episode. Early diagnosis with aggressive diagnostic techniques and use of combination therapy must be considered to reduce the risk of death in heart transplant recipients with fungal infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect