Pleural mesothelioma and lung cancer: the role of asbestos exposure and genetic variants in selected iron metabolism and inflammation genes
| Autor: | Ronald Moura, Violetta Borelli, L. Finotto, Fulvio Celsi, Manuela Schneider, Giuliano Zabucchi, Sergio Crovella, Francesca Vita, Paola Zacchi |
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| Přispěvatelé: | Celsi, F, Crovella, S, Moura, R R, Schneider, M, Vita, F, Finotto, L, Zabucchi, G, Zacchi, Paola, Borelli, V |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Mesothelioma Lung Neoplasms Hephaestin Inflammasomes Health Toxicology and Mutagenesis Toxicology medicine.disease_cause asbestos exposure 0302 clinical medicine iron Risk Factors Prevalence Aged 80 and over biology formalin-fixed and paraffin-embedded tissue samples hephaestin inflammasome lung cancer polymorphisms Inflammasome respiratory system Italy 030220 oncology & carcinogenesis formalin-fixed and paraffin-embedded tissue sample Female medicine.symptom medicine.drug Pleural Neoplasms Inflammation Asbestos 03 medical and health sciences medicine Humans Lung cancer Gene Aged Retrospective Studies business.industry Mesothelioma Malignant Metabolism medicine.disease respiratory tract diseases 030104 developmental biology Cancer research biology.protein business |
| Popis: | Two of the major cancerous diseases associated with asbestos exposure are malignant pleural mesothelioma (MPM) and lung cancer (LC). In addition to asbestos exposure, genetic factors have been suggested to be associated with asbestos-related carcinogenesis and lung genotoxicity. While genetic factors involved in the susceptibility to MPM were reported, to date the influence of individual genetic variations on asbestos-related lung cancer risk is still poorly understood. Since inflammation and disruption of iron (Fe) homeostasis are hallmarks of asbestos exposure affecting the pulmonary tissue, this study aimed at investigating the association between Fe-metabolism and inflammasome gene variants and susceptibility to develop LC or MPM, by comparing an asbestos-exposed population affected by LC with an "asbestos-resistant exposed population". A retrospective approach similar to our previous autopsy-based pilot study was employed in a novel cohort of autoptic samples, thus giving us the possibility to corroborate previous findings obtained on MPM by repeating the analysis in a novel cohort of autoptic samples. The protective role of HEPH coding SNP was further confirmed. In addition, the two non-coding SNPs, either in FTH1 or in TF, emerged to exert a similar protective role in a new cohort of LC exposed individuals from the same geographic area of MPM subjects. No association was found between NLRP1 and NLRP3 polymorphisms with susceptibility to develop MPM and LC. Further research into a specific MPM and LC "genetic signature" may be needed to broaden our knowledge of the genetic landscape attributed to result in MPM and LC. |
| Databáze: | OpenAIRE |
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