New butanolide derivatives from the marine derived fungus Aspergillus terreus GZU-31-1 by chemical epigenetic manipulation
| Autor: | Yuwei Zhou, Xiaocong Chen, Yuqian Tang, Yena Liu, Zhongxiang Zhao, Hui Cui |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Natural Product Research. :1-7 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2022.2140338 |
| Popis: | Chemical epigenetic manipulation of Aspergillus terreus GZU-31-1 led to the discovery of five butanolide derivatives (1–5), including two new ones (1 and 2), and four known diphenyl ether derivatives (6−9). Compound 1 featured a Z-configuration double bond in the isoprenyl group was a potential anti-inflammatory bioactive group. Compound 2 was a new natural product. Moreover, compound 3 with a deacetylated group at C-4 was rarely reported as a butanolide analogue, which was isolated from the liquid culture treated with polyketide pathway inhibitor sodium citrate dihydrate. All of the isolates (1−9) were tested for their anti-inflammatory effects on the production of nitric oxide in lipopolysaccharide-induced microglial cells (RAW 264.7 cells). Compounds 1, 7, 8 and 9 exhibited more potent anti-inflammatory activity with IC50 values of 16.31, 20.16, 9.53 and 21.64 μM than the positive control (indomethacin, IC50, 24.0 μM). |
| Databáze: | OpenAIRE |
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