The Prognostic Nutritional Index (PNI) is an independent predictor of overall survival in older patients with follicular lymphoma
| Autor: | Andrea Rivero, Alfredo Rivas-Delgado, Laura Magnano, Armando López-Guillermo, Pablo Mozas, Neus Villamor, Elias Campo, Patricia Pérez-Galán, Julio Delgado, Eva Giné, Ferran Nadeu |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Follicular lymphoma Nutritional Status Independent predictor Older patients Chemoimmunotherapy Internal medicine medicine Overall survival Humans Lymphoma Follicular Aged Retrospective Studies business.industry Absolute lymphocyte count Nutritional status Hematology medicine.disease Prognosis Survival Rate Nutrition Assessment business Prognostic Nutritional Index (PNI) |
| Zdroj: | Leukemialymphoma. 63(4) |
| ISSN: | 1029-2403 |
| Popis: | The Prognostic Nutritional Index (PNI), a parameter combining serum albumin concentration and absolute lymphocyte count, is considered a measure of the nutritional and inflammatory status and the host's anti-tumor response. We analyzed the clinical characteristics and outcomes according to the PNI of 351 grades 1-3 A FL patients. Forty-one patients (12%) had a PNI ≤45, who were older and showed adverse baseline features. A low PNI was associated with a shorter PFS (only for patients >60 years), and OS (for all patients, 10-year OS, 52% versus 74%, p = 0.0001). The prognostic impact of the PNI on OS was confirmed in a multivariate model for patients >60 years (HR = 3, p = 0.006). In conclusion, the PNI is a readily accessible piece of information that can identify a small subset of FL patients with shorter survival, and it could be an aid to improve the nutritional status of patients prior to treatment initiation. |
| Databáze: | OpenAIRE |
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