Correlates of the ratio of acceleration time to ejection time in patients with aortic stenosis: An echocardiographic and computed tomography study

Autor: Laurent Macron, Manuel Toledano, A. Altes, A. Truffier, Cédric Renard, Sylvestre Maréchaux, Yohann Bohbot, Pierre Graux, Gagandeep Chadha, Raphaëlle-Ashley Guerbaai, Julien Dreyfus, Pierre Vladimir Ennezat, Christophe Tribouilloy, David Attias, M. Sochala
Přispěvatelé: Centre cardiologique du Nord (CCN), CHU Amiens-Picardie, University of Basel (Unibas), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
medicine.medical_specialty
Time Factors
[SDV]Life Sciences [q-bio]
Acceleration
Hemodynamics
Computed tomography
Acceleration time
030204 cardiovascular system & hematology
Severity of Illness Index
Ventricular Function
Left
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Internal medicine
medicine
Humans
In patient
030212 general & internal medicine
Registries
ComputingMilieux_MISCELLANEOUS
Aged
Retrospective Studies
Aged
80 and over
Univariate analysis
Ejection fraction
medicine.diagnostic_test
business.industry
Calcinosis
Stroke Volume
General Medicine
Aortic Valve Stenosis
medicine.disease
Prognosis
Echocardiography
Doppler
Stenosis
Blood pressure
Aortic valve stenosis
Aortic Valve
Cardiology
Female
France
Ejection time
Cardiology and Cardiovascular Medicine
business
Tomography
X-Ray Computed
Zdroj: Archives of cardiovascular diseases
Archives of cardiovascular diseases, Elsevier/French Society of Cardiology, 2019, 112, pp.567-575. ⟨10.1016/j.acvd.2019.06.004⟩
ISSN: 1875-2136
DOI: 10.1016/j.acvd.2019.06.004⟩
Popis: An increased acceleration time to ejection time (AT/ET) ratio is associated with increased mortality in patients with aortic stenosis (AS).To identify the factors associated with an increased AT/ET ratio.The relationships between the AT/ET ratio and clinical and Doppler echocardiographic variables of interest in the setting of AS were analysed retrospectively in 1107 patients with AS and preserved left ventricular (LV) ejection fraction (LVEF). The computed tomography aortic valve calcium (CT-AVC) score was studied in a subgroup of 342 patients.In the univariate analysis, the AT/ET ratio was found to correlate with peak aortic jet velocity (r=0.57; P0.0001), mean pressure gradient (r=0.60; P0.0001), aortic valve area (r=-0.50; P0.0001) and CT-AVC score (r=0.24; P0.0001). The AT/ET ratio had good accuracy in predicting a peak aortic jet velocity≥4 m/s, a mean pressure gradient≥40mmHg and an aortic valve area≤1.0cmThe AT/ET ratio is related to echocardiographic and CT-AVC indices of AS severity. However, multiple intricate factors beyond the haemodynamic and anatomical severity of AS influence the AT/ET ratio, including LV geometry, function and systolic blood pressure. These findings should be considered when assessing the AT/ET ratio in patients with AS and preserved LVEF.
Databáze: OpenAIRE
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