Influenza-associated Neurologic Complications in Hospitalized Pediatric Patients: A Multicenter Retrospective Study in Republic of Korea
| Autor: | Young-Jong Woo, Ji Young Park, Jun Hwa Lee, Gwang-Jun Choi, Kim Di, Jeehun Lee, Yae-Jean Kim, J.-H Choi, Sae Rom Choi |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Male Pediatrics medicine.medical_specialty Myocarditis Adolescent Encephalopathy Antiviral Agents Seizures Febrile Influenza A Virus H1N1 Subtype Oseltamivir Risk Factors Convulsion Influenza Human Republic of Korea medicine Humans Risk factor Child Retrospective Studies Brain Diseases business.industry Infant Retrospective cohort study Odds ratio medicine.disease Hospitalization Infectious Diseases Child Preschool Pediatrics Perinatology and Child Health Female medicine.symptom business Meningitis Encephalitis |
| Zdroj: | The Pediatric infectious disease journal. 40(12) |
| ISSN: | 1532-0987 |
| Popis: | The rates of influenza-associated neurologic complications are variable among studies, and a difference has been observed between the Western and Asian countries. The study aims to evaluate the frequency and characteristics of influenza-associated neurologic complications.We performed a retrospective review of hospitalized cases of influenza infection from October 2010 to April 2017 from 3 referral hospitals.A total of 1988 influenza cases were identified. Influenza-associated neurologic complications were 161 cases (8.1%); influenza virus A was detected in 113 (70.2%) cases, B in 47 (29.2%) cases and both A and B in 1 case (0.6%). Twenty-four patients (15%) had underlying neurologic diseases. The most common diagnosis was a simple febrile convulsion (44%), followed by complex febrile convulsion (29%), fever-provoked seizure under pre-existing neurologic disease or afebrile seizure (14%), encephalopathy/encephalitis (8%) and meningitis (5%). Most of the patients fully recovered (96%). Three patients (1.9%) died of myocarditis (n = 1), encephalopathy (n = 1), and simultaneous encephalitis and myocarditis (n = 1). Pre-existing neurologic disease, age groups of 6 months to 6 years and 6-12 years were a risk factor of influenza-associated neurologic complications with an adjusted odds ratio of 5.41 (95% confidence interval [CI] 3.23-9.06, P0.001), 12.99 (95% CI 1.77-95.19, P = 0.01) and 8.54 (95% CI 1.14-64.79, P = 0.04), respectively. There was no association between neuropsychiatric adverse events and oseltamivir prescription (P = 0.17).Influenza-associated neurologic complications are not uncommon, and most patients fully recovered. The frequency of influenza-associated neurologic complications in Korean children was not significantly different from that of children in Western countries. |
| Databáze: | OpenAIRE |
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