Effectiveness of combination therapy of splenectomy and long-term interferon in patients with hepatitis C virus-related cirrhosis and thrombocytopenia
| Autor: | Hiromi Saneto, Hiromi Yatuji, Tetuya Hosaka, Yoshiyuki Suzuki, Masahiro Kobayashi, Hiromitu Kumada, Daisuke Morihara, Fumitaka Suzuki, Yusuke Kawamura, Norio Akuta, Hitomi Sezaki, Kenji Ikeda |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Cirrhosis Hepatology Combination therapy business.industry medicine.medical_treatment Hepatitis C virus Splenectomy Immunotherapy Hepatitis C medicine.disease medicine.disease_cause Gastroenterology Group B Infectious Diseases Internal medicine Immunology medicine business Survival rate |
| Zdroj: | Hepatology Research. 39:439-447 |
| ISSN: | 1872-034X 1386-6346 |
| DOI: | 10.1111/j.1872-034x.2008.00481.x |
| Popis: | Aim: To elucidate the effectiveness of combination therapy of splenectomy and long-term interferon (IFN) on survival and hepatocarcinogenesis, we retrospectively analyzed 180 patients with hepatitis C virus (HCV)-related cirrhosis and thrombocytopenia. Methods: Group A consisted of 121 patients who received neither splenectomy nor IFN therapy. Group B consisted of 11 patients who underwent splenectomy only. Group C consisted of 32 patients who underwent IFN therapy only. Group D consisted of 16 patients who received the combination therapy splenectomy followed by IFN therapy. Results: The viral response in group D estimated at least 6 months after IFN therapy showed sustained viral response in four patients, biochemical response in one and no response in six. Multivariate analysis using time-dependent variables showed significant improvement of survival rate in patients on the combination therapy,but no effect on the appearance rate of hepatocarcinogenesis relative to the findings in group A. Conclusions: In this study, the splenectomy did not directly improve the prognosis, but increased the ability for patients to undergo IFN. As a result, we considered that the combination therapy of splenectomy and long-term IFN significantly improved survival rate in patients with advanced HCV-related cirrhosis and thrombocytopenia. |
| Databáze: | OpenAIRE |
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