Sodium-Glucose Cotransporter 2 Inhibitors Reduce Prandial Insulin Doses in Type 2 Diabetic Patients Treated With the Intensive Insulin Therapy
| Autor: | Hidekatsu Yanai, Kouki Kakuta, Hiroki Adachi, Mariko Hakoshima |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Urinary system Type 2 diabetes 030204 cardiovascular system & hematology Hypoglycemia Urinary glucose excretion Sodium-glucose cotransporter 2 inhibitor Excretion 03 medical and health sciences 0302 clinical medicine Internal medicine medicine 030212 general & internal medicine Kidney business.industry Insulin General Medicine Body weight Intensive insulin therapy medicine.disease medicine.anatomical_structure Endocrinology Postprandial Hemoglobin A1c Sodium/Glucose Cotransporter 2 Original Article business |
| Zdroj: | Journal of Clinical Medicine Research |
| ISSN: | 1918-3011 1918-3003 |
| DOI: | 10.14740/jocmr3392w |
| Popis: | Background: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are anti-diabetic drugs which improve blood glucose control by blocking reabsorption of glucose from the proximal tubule of kidney. Anti-atherosclerotic properties and cardiovascular protective effects of SGLT2i have been demonstrated by recent studies; however, the efficacy and safety of addition of SGLT2i to the intensive insulin therapy remain largely unknown. Methods: We retrospectively picked up patients hospitalized for treatment of type 2 diabetes, who had been treated by the intensive insulin therapy and whose treatment using by SGLT2i started during their hospitalization. Such patients were picked up between June 2014 and May 2017 based on medical charts. Results: We found 12 eligible patients. Observation period was 10.2 ± 4.7 days, and SGLT2i was started at 12.2 ± 12.9 days after the admission. During observation period, nobody developed hypoglycemia. In spite of showing decrease of blood glucose (non-significant) before each meal, the addition of SGLT2i significantly reduced daily prandial insulin doses by approximately 4.6 units/day (-66%). The SGLT2i addition also decreased body weight by approximately 1.3 kg. Conclusion: Present study demonstrated that the addition of SGLT2i to intensive insulin therapy reduced prandial insulin doses and body weight, without the development of hypoglycemia. This result may be due to SGLT2i-mediated improvement of postprandial hyperglycemia by increasing urinary glucose excretion not via insulin secretion. J Clin Med Res. 2018;10(6):493-498 doi: https://doi.org/10.14740/jocmr3392w |
| Databáze: | OpenAIRE |
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