Advances in Synthesis and Medicinal Applications of Compounds Derived from Phthalimide
| Autor: | Maria Clarissa Oliveira, Marcel L. Almeida, Marina Galdino da Rocha Pitta, Ivan da Rocha Pitta |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Antitumor activity
010405 organic chemistry Organic Chemistry Phthalimides 01 natural sciences Biochemistry Chemical synthesis Combinatorial chemistry 0104 chemical sciences Phthalimide 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Cell Line Tumor Sedative Effects Animals Humans |
| Zdroj: | Current Organic Synthesis. 17:252-270 |
| ISSN: | 1570-1794 |
| DOI: | 10.2174/1570179417666200325124712 |
| Popis: | Phthalimide derivatives have been presenting several promising biological activities in the literature, such as anti-inflammatory, analgesic, antitumor, antimicrobial and anticonvulsant. The most well-known and studied phthalimide derivative (isoindoline-1,3-dione) is thalidomide: this compound initially presented important sedative effects, but it is now known that thalidomide has effectiveness against a wide variety of diseases, including inflammation and cancer. This review approaches some of the recent and efficient chemical synthesis pathways to obtain phthalimide analogues and also presents a summary of the main biological activities of these derivatives found in the literature. Therefore, this review describes the chemical and therapeutic aspects of phthalimide derivatives. |
| Databáze: | OpenAIRE |
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