Dynamics and Determinants of Pneumococcal Antibodies Specific against 13 Vaccine Serotypes in the Pre-Vaccination Era

Autor: Karin E. M. Elberse, Hester E. de Melker, Mirjam J. Knol, Annemarijn C. Prins-van Ginkel, Irina Tcherniaeva, Jelle I. Wittenberns, Liesbeth Mollema, Guy A. M. Berbers, Lucienne H. Grundeken
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Serotype
Male
Pulmonology
Physiology
lcsh:Medicine
medicine.disease_cause
Pathology and Laboratory Medicine
Biochemistry
Immunoglobulin G
Pneumococcal Vaccines
Families
0302 clinical medicine
Elderly
Immune Physiology
Medicine and Health Sciences
Ethnicities
Public and Occupational Health
030212 general & internal medicine
lcsh:Science
Non-U.S. Gov't
Child
Children
Vaccines
COPD
Multidisciplinary
Immune System Proteins
biology
Research Support
Non-U.S. Gov't
Vaccination
Bacterial
Pneumococcus
Middle Aged
Vaccination and Immunization
Antibodies
Bacterial
Bacterial Pathogens
Pneumococcal infections
Streptococcus pneumoniae
Medical Microbiology
Child
Preschool
Female
Antibody
Pathogens
Research Article
Adult
Adolescent
Immunology
Research Support
Serogroup
Microbiology
Antibodies
Pneumococcal Infections
03 medical and health sciences
Young Adult
030225 pediatrics
medicine
Journal Article
Humans
Preschool
Microbial Pathogens
Aged
Conjugate
Vaccines
Conjugate
Bacteria
business.industry
lcsh:R
Organisms
Infant
Newborn
Biology and Life Sciences
Proteins
Streptococcus
Infant
Newborn
medicine.disease
Asthma
Carriage
Cross-Sectional Studies
Age Groups
People and Places
biology.protein
lcsh:Q
Population Groupings
Preventive Medicine
business
Zdroj: PLoS ONE
PLoS ONE, Vol 11, Iss 1, p e0147437 (2016)
PLoS ONE [E], 11(1). Public Library of Science
ISSN: 1932-6203
Popis: INTRODUCTION: Introduction of pneumococcal conjugate vaccines (PCVs) for infants decreased overall invasive pneumococcal disease (IPD), while non-vaccine serotype IPD increased. To fully understand this serotype replacement, knowledge about serotype dynamics in the pre-vaccine era is needed. In addition to IPD surveillance and carriage studies, the serotype replacement can be investigated by serosurveillance studies. The current study compared the results of two Dutch serosurveillance studies conducted in 1995-1996 (PIENTER1) and 2006-2007 (PIENTER2). METHODS: Participants in these studies donated a blood sample and completed a questionnaire. Pneumococcal antibodies of serotypes included in PCV13 were measured with a fluorescent-bead based multiplex immunoassay. Geometric mean antibody concentrations (GMCs) and determinants of pneumococcal antibody levels were investigated. RESULTS: GMCs were higher in PIENTER2 for serotypes 1, 6A, 6B, 9V, 18C, 19F and 23F and lower for 3 and 5. Age, day care attendance, household size, vaccination coverage, and urbanisation rate were associated with pneumococcal antibodies in children. Education level, ethnicity, age, low vaccination coverage sample, urbanisation rate, and asthma/COPD were associated with pneumococcal antibodies in elderly. The determinants significantly associated with pneumococcal IgG were slightly different for the elderly in PIENTER1 compared to the elderly in PIENTER2. CONCLUSION: Although most of the serotype antibody levels remained stable, some of the serotype-specific antibody levels varied during the pre-vaccine era, indicating that exposure of certain serotypes changes without interference of PCVs.
Databáze: OpenAIRE
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