Supplementary Figures S1-6 from Pharmacologic Inhibition of JAK1/JAK2 Signaling Reduces Experimental Murine Acute GVHD While Preserving GVT Effects

Autor: Jacopo Mariotti, Paolo Corradini, Anisa Bermema, Davide Confalonieri, Camilla Recordati, Antonio Vendramin, Silvia Gimondi, Cristiana Carniti
Rok vydání: 2023
DOI: 10.1158/1078-0432.22457555
Popis: Supplementary Figures S1-6. Figure S1: Histological staging criteria for acute GvHD Figure S2: Ruxolitinib does not impair post-transplant donor myeloid reconstitution and full donor chimerism. Figure S3: GVT effect against myeloid leukemia RMB-1 cell line is maintained in the presence of ruxolitinib Figure S4: Ruxolitinib at the dose of 90 mg/Kg prevents acute GVHD without affecting T cell alloreactivity Figure S5: Ruxolitinib effect at 45 mg/Kg on absolute numbers of alloreactive T cells, Th17 and Treg cells. Figure S6: Representative Images of Ruxolitinb effect on T cells and macrophage infiltration of GVHD organs
Databáze: OpenAIRE