| Autor: |
Ryoji Yokota, Shigetake Sasayama, Masami Miyamae, Hisayoshi Fujiwara, Masaru Tanaka, Kenzo Yamasaki |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
Journal of the American College of Cardiology. 25:355A |
| ISSN: |
0735-1097 |
| DOI: |
10.1016/0735-1097(95)92928-x |
| Popis: |
Ischemic preconditioning (PC) with 5-min ischemia(l) and reperiusion (R) limits infarct size (IS) after subsequent I in rabbits. The aim of this study was to evaluate whether PC with longer I was also protective. Open chest rabbits underwent 30-min occlusion of coronary artery and 48-hrs R. PC was elicited by either a preceding 5-, 10- or 15-min I followed by 5-min R. Additional group underwent 15-min 1a 48-hrs R. IS was measured histologically and expressed as a percentage of the area at risk (AAR). Group AAR(%LV) IS (%LV) IS (%AAR) non-PC (n = 15) 26.7 ± 2.1 11.1 ± 1.5 40.1 ± 3.8 5-min PC (n = 10) 26.7 ± 2.7 3.1 ± 1.0 * 10.4 ± 2.9 * 10-min PC (n = 10) 28.4 ± 3.1 3.5 ± 0.9 * 11.7 ± 2.4 * 15-min PC(n = 15) 25.S ± 1.8 20.1 ± 1.9 * # b 77.4 ± 3.7 * # b 15-min I (n = 10) 2S.3 ± 3.8 5.4 ± 1.0 * 18.3 ± 1.0 * * p l 0.05 vs. non-PC # p l 0.05 vs. 5 min PC b p l 0.05 vs. 10 min PC Since 15-min I caused infarct (18% of AAR). IS caused by test I per se in 15-min PC group was 59.5 ± 3.7% of AAR (p l 0.05 vs. non PC). Thus, PC with 10-min I is as protective as that with 5-min I. However, PC with 15-min I accelerated myocyte necrosis during subsequent I. Conclusion We conclude that ischemic duration of PC is a determinant of its cardioprotection, and PC with too long ischemia is not protective but harmful. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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