Hypotensive and neurometabolic effects of intragastric Reishi (Ganoderma lucidum) administration in hypertensive ISIAH rat strain
| Autor: | L. V. Kuibida, E. L. Zavjalov, Tatiana N. Goryachkovskaya, L. A. Gerlinskaya, Arcady L. Markel, Mikhail P. Moshkin, Sergey E. Peltek, Nikolay M. Slynko, A. A. Seryapina, Oleg B. Shevelev |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Reishi Adult male гипотензивное действие Pharmaceutical Science Blood Pressure повышенное кровяное давление 030204 cardiovascular system & hematology Pharmacology Losartan Nootropic 03 medical and health sciences 0302 clinical medicine Drug Discovery Animals Medicine Antihypertensive Agents Nootropic Agents Ganoderma lucidum Cerebral Cortex business.industry Rats Inbred Strains Rat strain трутовик лакированный Carotid Arteries Blood pressure medicine.anatomical_structure Complementary and alternative medicine Cerebral blood flow Cerebral cortex Cerebrovascular Circulation Dietary Supplements Hypertension Molecular Medicine business нейрометаболическое действие 030217 neurology & neurosurgery Phytotherapy medicine.drug |
| Zdroj: | Phytomedicine. 2018. Vol. 41. P. 1-6 |
| Popis: | Background As the standard clinically used hypotensive medicines have many undesirable side effects, there is a need for new therapeutic agents, especially ones of a natural origin. Purpose One possible candidate is extract from the mushroom Reishi (Ganoderma lucidum), which is used in the treatment and prevention of many chronic diseases. Study design and methods To study the effectiveness of Reishi, which grows in the Altai Mountains, as an antihypertensive agent, we intragastrically administered Reishi water extract to adult male hypertensive ISIAH (inherited stress-induced arterial hypertension) rats. Results After seven weeks, Reishi therapy reduced blood pressure in experimental animals at a level comparable to that of losartan. Unlike losartan, intragastric Reishi introduction significantly increases cerebral blood flow and affects cerebral cortex metabolic patterns, shifting the balance of inhibitory and excitatory neurotransmitters toward excitation. Conclusion Changes in cerebral blood flow and ratios of neurometabolites suggests Reishi has a potential nootropic effect. |
| Databáze: | OpenAIRE |
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