Neuropathy and presence of emotional distress and depression in longstanding diabetes: Results from the Canadian study of longevity in type 1 diabetes
| Autor: | Michael H. Brent, Genevieve Boulet, Julie A. Lovshin, Mohammed A. Farooqi, Alanna Weisman, Vera Bril, Devrim Eldelekli, Marina Cardinez, Yuliya Lytvyn, David Z.I. Cherney, Narinder Paul, Bruce A. Perkins, Elise M. Halpern, Leif E. Lovblom, Johnny-Wei Bai, Hillary A. Keenan |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Risk medicine.medical_specialty Aging Canada Diabetic neuropathy Cross-sectional study Endocrinology Diabetes and Metabolism Longevity 030209 endocrinology & metabolism Cohort Studies 03 medical and health sciences 0302 clinical medicine Endocrinology Cost of Illness Diabetic Neuropathies Stress Physiological Diabetes mellitus Internal medicine Internal Medicine medicine Prevalence Humans 030212 general & internal medicine Poisson Distribution Depression (differential diagnoses) Aged Aged 80 and over Psychiatric Status Rating Scales Type 1 diabetes Depressive Disorder Major business.industry Middle Aged medicine.disease Survival Analysis Distress Cross-Sectional Studies Diabetes Mellitus Type 1 Physical therapy Quality of Life Geriatric Depression Scale Female business Cohort study |
| Zdroj: | Journal of diabetes and its complications. 31(8) |
| ISSN: | 1873-460X |
| Popis: | To determine the association of neuropathy and other complications with emotional distress and depression among patients with longstanding type 1 diabetes (T1DM).Canadians with ≥50years of T1DM completed a questionnaire including assessment of distress and depression by the Problem Areas in Diabetes Scale (PAID) and Geriatric Depression Scale (GDS), respectively. Complications were determined using the Michigan Neuropathy Screening Instrument (Questionnaire Component), fundoscopy reports, renal function tests, and self-reported peripheral-(PVD) and cardiovascular (CVD) disease. Associations were analyzed by Poisson regression.Among 323 participants, 137 (42.4%) had neuropathy, 113 (36.5%) nephropathy, 207 (69.5%) retinopathy, 95 (29.4%) CVD, and 31 (9.8%) PVD. The neuropathy subgroup had higher prevalence of distress (13 (9.5%) vs. 6 (3.3%), p=0.029) and depression (34 (24.9%) vs. 12 (6.5%), p0.001). Adjusting for diabetes complications, neuropathy was associated with higher PAID (adjusted RR 1.44 (95% CI 1.14-1.82), p=0.003) and GDS scores (adjusted RR1.57 (1.18-2.11), p=0.002). Independent of potential confounders, neuropathy remained associated with higher PAID (adjusted RR 1.39 (1.10-1.76), p=0.006) and GDS scores (adjusted RR 1.37 (1.03-1.83), p=0.032). Associations with neuropathy were not fully explained by neuropathic pain.Compared to other complications, neuropathy had the greatest association with distress and depression in longstanding T1DM, independent of pain. Strategies beyond pain management are needed to improve quality of life in diabetic neuropathy. |
| Databáze: | OpenAIRE |
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