Global DNA Methylation in Neonatal Sepsis
| Autor: | Banupriya Newton, Hiasindh Ashmi Antony, Vishnu Bhat, Benet Bosco Dhas, Subhash Chandra Parija |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Birth weight Gestational Age Sensitivity and Specificity Gastroenterology Infant Newborn Diseases Epigenesis Genetic Sepsis Internal medicine medicine Birth Weight Humans Epigenetics Neonatal sepsis business.industry Infant Newborn Reproducibility of Results Gestational age Methylation DNA Methylation Prognosis medicine.disease genomic DNA Pediatrics Perinatology and Child Health DNA methylation Immunology 5-Methylcytosine Female business Biomarkers |
| Zdroj: | The Indian Journal of Pediatrics. 82:340-344 |
| ISSN: | 0973-7693 0019-5456 |
| DOI: | 10.1007/s12098-014-1574-5 |
| Popis: | To find out whether gDNA methylation can be used as a diagnostic/prognostic method for neonatal sepsis. The study was conducted in the neonatal division of a tertiary care referral hospital. Fifty one newborns as cases and thirty seven newborns as controls were enrolled in the study. Using 5-mC DNA ELISA method, the percentage of genomic DNA methylated in these newborns was established. Highly significant difference in percentage of gDNA methylated was found between the cases and controls (Cases: 2.4 ± 0.39; Controls: 2.07 ± 0.35; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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