Does the activity of the combination of imipenem and colistin in vitro exceed the problem of resistance in metallo-beta-lactamase-producing Klebsiella pneumoniae isolates?
| Autor: | Panagiota Danai Rekatsina, Maria Souli, Irene Galani, Zoi Chryssouli, Helen Giamarellou, Kyriaki Kanellakopoulou |
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| Rok vydání: | 2009 |
| Předmět: |
Imipenem
Klebsiella pneumoniae medicine.drug_class medicine.medical_treatment Antibiotics Drug resistance Microbial Sensitivity Tests beta-Lactamases Microbiology Drug Resistance Bacterial medicine polycyclic compounds Humans Pharmacology (medical) Drug Interactions Antibacterial agent Pharmacology biology Colistin biochemical phenomena metabolism and nutrition biology.organism_classification bacterial infections and mycoses Anti-Bacterial Agents Infectious Diseases Synergy Susceptibility Beta-lactamase bacteria lipids (amino acids peptides and proteins) Drug Therapy Combination medicine.drug |
| Zdroj: | Antimicrobial agents and chemotherapy. 53(5) |
| ISSN: | 1098-6596 |
| Popis: | Using time-kill methodology, we investigated the interactions of an imipenem-colistin combination against 42 genetically distinct Klebsiella pneumoniae clinical isolates carrying a bla VIM-1 -type gene. Irrespective of the imipenem MIC, the combination was synergistic (50%) or indifferent (50%) against colistin-susceptible strains, while it was antagonistic (55.6%) and rarely synergistic (11%) against non-colistin-susceptible strains (with synergy being observed only against strains with colistin MICs of 3 to 4 μg/ml). The combination showed improved bactericidal activity against isolates susceptible either to both agents or to colistin. |
| Databáze: | OpenAIRE |
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