Serum Levels of M2BPGi as Short-Term Predictors of Hepatocellular Carcinoma in Untreated Chronic Hepatitis B Patients

Autor:	Li Yu Wang, Masashi Mizokami, Hwai I. Yang, Masaaki Korenaga, Sheng Nan Lu, Chin Lan Jen, Jessica Liu, Richard Batrla-Utermann, Mei Hsuan Lee, Chien-Jen Chen, Hui Han Hu
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	Adult Liver Cirrhosis Male medicine.medical_specialty HBsAg Carcinoma Hepatocellular lcsh:Medicine Logistic regression Antiviral Agents Gastroenterology Article 03 medical and health sciences Hepatitis B Chronic 0302 clinical medicine Antigen Chronic hepatitis Antigens Neoplasm Internal medicine Biomarkers Tumor Carcinoma medicine Humans lcsh:Science neoplasms Aged Glycoproteins Hepatitis B Surface Antigens Multidisciplinary business.industry Liver Neoplasms lcsh:R Case-control study Middle Aged Hepatitis B Prognosis medicine.disease digestive system diseases ROC Curve Area Under Curve Case-Control Studies 030220 oncology & carcinogenesis Hepatocellular carcinoma Female 030211 gastroenterology & hepatology lcsh:Q alpha-Fetoproteins Carrier Proteins business
Zdroj:	Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017) Scientific Reports
ISSN:	2045-2322
DOI:	10.1038/s41598-017-14747-5
Popis:	This study examines the role of M2BPGi, a novel seromarker for chronic hepatitis, in predicting hepatocellular carcinoma (HCC) among untreated chronic hepatitis B (CHB) patients. In this nested case-control study, 1070 samples were assayed for M2BPGi, including 357 samples from HCC cases, and 713 samples from non-HCC controls, collected at various times throughout follow-up. HCC case samples were stratified according to years prior to diagnosis. Associations between M2BPGi and HCC were examined with multivariate logistic regression. M2BPGi, α-fetoprotein (AFP), and hepatitis B surface antigen (HBsAg) levels were significant independent short-term predictors of HCC, while M2BPGi was insignificant in long-term analyses. Compared to M2BPGi levels 5 years were 0.84, 0.81, and 0.75. M2BPGi is a strong and independent short-term predictor of HCC in CHB patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed6f54c095466367926837649dca14b http://link.springer.com/article/10.1038/s41598-017-14747-5 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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