Patient age and positive margins are predictive factors of residual tumor on mastectomy specimen after conservative treatment for breast cancer
| Autor: | Thomas Hebert, Philippe Porée, Henri Marret, Jean Lévêque, Habiba Mesbah, Laure Voguet, Gilles Body, Olivier Acker |
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| Rok vydání: | 2008 |
| Předmět: |
Oncology
Adult medicine.medical_specialty Neoplasm Residual medicine.drug_class medicine.medical_treatment Estrogen receptor Breast Neoplasms Mastectomy Segmental Breast cancer Risk Factors Internal medicine Progesterone receptor medicine Humans Lymph node Mastectomy Aged Univariate analysis business.industry Lumpectomy Carcinoma Ductal Breast Age Factors General Medicine Middle Aged medicine.disease Carcinoma Lobular medicine.anatomical_structure Carcinoma Intraductal Noninfiltrating Receptors Estrogen Estrogen Multivariate Analysis Surgery Female Radiology business |
| Zdroj: | Breast (Edinburgh, Scotland). 18(4) |
| ISSN: | 1532-3080 |
| Popis: | Aims To determine factors predictive of the presence of residual tumor on the specimen from mastectomy performed after conservative treatment for breast cancer in order to limit potentially unnecessary mastectomies (free of residual lesions). Materials and methods 294 patients treated in 2 expert centers for breast cancer with breast-conserving therapy (BCT) followed by mastectomy, according to French recommendations, were investigated between January 1, 1998 and January 1, 2005. Patients with residual tumor on the mastectomy specimen were compared with patients whose mastectomy specimens did not reveal any residual tumor. All the clinical risk factors (age, previous history of breast cancer, tumor focality) and histological risk factors (tumor size, histological type, positive margins, estrogen and progesterone receptor expression, histological grade) for residual tumor after BCT were compared between the 2 patient groups. Results Of the 294 patients studied, 202 (68.71%) mastectomies had residual tumor and 92 (31.29%) were tumor-free. Four predictive factors for residual tumor were found in the univariate analysis: age under 45 years ( p =0.01), absence of estrogen receptor expression ( p =0.05), positive margins ( p =0.01), and presence of lymph node metastases ( p =0.05). The multivariate analysis revealed only 2 independent risk factors that were significantly associated with increased risk of residual tumor on the mastectomy specimen: age under 45 years ( p =0.05) and presence of positive margins on the lumpectomy specimen ( p =0.05). Conclusion Young age of patients (under 45-years-old) and presence of positive margins on the operative specimen are independent risk factors of residual tumor after conservative treatment of breast cancer. |
| Databáze: | OpenAIRE |
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