Imputation strategies for missing baseline neurological assessment covariates after traumatic brain injury: A CENTER-TBI study
| Autor: | Ari Ercole, Fiona Lecky, Frederick A. Zeiler, Abhishek Dixit, Participants, Ewout W. Steyerberg, Omar Bouamra, Daan Nieboer, Andrew I R Maas, David K. Menon, David W. Nelson, Lindsay Wilson, Center-Tbi investigators, Hester F. Lingsma, Simone A. Dijkland, Shubhayu Bhattacharyay |
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| Přispěvatelé: | Ercole, Ari [0000-0001-8350-8093], Bhattacharyay, Shubhayu [0000-0001-7428-5588], Maas, Andrew I. R. [0000-0003-1612-1264], Wilson, Lindsay [0000-0003-4113-2328], Apollo - University of Cambridge Repository, Freo, Ulderico, Frisvold, Shirin, Furmanov, Alex, Gagliardo, Pablo, Galanaud, Damien, Gao, Guoyi, Geleijns, Karin, Ghuysen, Alexandre, Giraud, Benoit, Glocker, Ben, Gomez, Pedro A., Grossi, Francesca, Gruen, Russell L., Gupta, Deepak, Haagsma, Juanita A., Hadzic, Ermin, Haitsma, Iain, Hartings, Jed A., Helbok, Raimund, Helseth, Eirik, Hertle, Daniel, Hill, Sean, Hoedemaekers, Astrid, Hoefer, Stefan, Hutchinson, Peter J., Haberg, Asta Kristine, Jacobs, Bram, Janciak, Ivan, Janssens, Koen, Jiang, Ji-yao, Jones, Kelly, Kalala, Jean-Pierre, Kamnitsas, Konstantinos, Karan, Mladen, Karau, Jana, Katila, Ari, Kaukonen, Maija, Keeling, David, Kerforne, Thomas, Ketharanathan, Naomi, Kettunen, Johannes, Kivisaari, Riku, Kolias, Angelos G., Kolumbán, Bálint, Kompanje, Erwin, Kondziella, Daniel, Koskinen, Lars-Owe, Kovács, Noémi, Kálovits, Ferenc, Lagares, Alfonso, Adams, Hadie, Lanyon, Linda, Laureys, Steven, Lauritzen, Martin, Lecky, Fiona, Ledig, Christian, Lefering, Rolf, Legrand, Valerie, Lei, Jin, Levi, Leon, Lightfoot, Roger, Alessandro, Masala, Lingsma, Hester, Loeckx, Dirk, Lozano, Angels, Luddington, Roger, Luijten-Arts, Chantal, Maas, Andrew I. R., MacDonald, Stephen, MacFayden, Charles, Maegele, Marc, Majdan, Marek, Allanson, Judith, Major, Sebastian, Manara, Alex, Manhes, Pauline, Manley, Geoffrey, Martin, Didier, Martino, Costanza, Maruenda, Armando, Maréchal, Hugues, Mastelova, Dagmara, Mattern, Julia, Amrein, Krisztina, McMahon, Catherine, Melegh, Béla, Menon, David, Menovsky, Tomas, Morganti-Kossmann, Cristina, Mulazzi, Davide, Mutschler, Manuel, Mühlan, Holger, Negru, Ancuta, Nelson, David, Andaluz, Norberto, Neugebauer, Eddy, Newcombe, Virginia, Noirhomme, Quentin, Nyirádi, József, Oddo, Mauro, Oldenbeuving, Annemarie, Oresic, Matej, Ortolano, Fabrizio, Palotie, Aarno, Parizel, Paul M., Andelic, Nada, Patruno, Adriana, Payen, Jean-François, Perera, Natascha, Perlbarg, Vincent, Persona, Paolo, Peul, Wilco, Pichon, Nicolas, Piilgaard, Henning, Piippo, Anna, Pili, Floury Sébastien, Andrea, Nanni, Pirinen, Matti, Ples, Horia, Polinder, Suzanne, Pomposo, Inigo, Psota, Marek, Pullens, Pim, Puybasset, Louis, Ragauskas, Arminas, Raj, Rahul, Rambadagalla, Malinka, Andreassen, Lasse, Rehorc̆íková, Veronika, Rhodes, Jonathan, Richardson, Sylvia, Ripatti, Samuli, Rocka, Saulius, Rodier, Nicolas, Roe, Cecilie, Roise, Olav, Roks, Gerwin, Romegoux, Pauline, Anke, Audny, Rosand, Jonathan, Rosenfeld, Jeffrey, Rosenlund, Christina, Rosenthal, Guy, Rossaint, Rolf, Rossi, Sandra, Rostalski, Tim, Rueckert, Daniel, Ruiz de Arcaute, Felix, Rusnák, Martin, Antoni, Anna, Sacchi, Marco, Sahakian, Barbara, Sahuquillo, Juan, Sakowitz, Oliver, Sala, Francesca, Sanchez-Pena, Paola, Sanchez-Porras, Renan, Sandor, Janos, Santos, Edgar, Sasse, Nadine, Audibert, Gérard, Sasu, Luminita, Savo, Davide, Schipper, Inger, Schlößer, Barbara, Schmidt, Silke, Schneider, Annette, Schoechl, Herbert, Schoonman, Guus, Ardon, Hilko, Schou, Rico Frederik, Auslands, Kaspars, Schwendenwein, Elisabeth, Schöll, Michael, Sir, özcan, Skandsen, Toril, Smakman, Lidwien, Smeets, Dirk, Smielewski, Peter, Sorinola, Abayomi, Stamatakis, Emmanuel, Stanworth, Simon, Azouvi, Philippe, Stegemann, Katrin, Steinbüchel, Nicole, Stevens, Robert, Stewart, William, Steyerberg, Ewout W., Stocchetti, Nino, Sundström, Nina, Synnot, Anneliese, Szabó, József, Söderberg, Jeannette, Baciu, Camelia, Taccone, Fabio Silvio, Tamás, Viktória, Tanskanen, Päivi, Tascu, Alexandru, Taylor, Mark Steven, Te, Ao Braden, Tenovuo, Olli, Teodorani, Guido, Theadom, Alice, Thomas, Matt, Bacon, Andrew, Tibboel, Dick, Tolias, Christos, Tshibanda, Jean-Flory Luaba, Tudora, Cristina Maria, Vajkoczy, Peter, Valeinis, Egils, Van Hecke, Wim, Van Praag, Dominique, Van Roost, Dirk, Van Vlierberghe, Eline, Badenes, Rafael, Vande Vyvere, Thijs, Vanhaudenhuyse, Audrey, Vargiolu, Alessia, Vega, Emmanuel, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, Vizzino, Giacinta, Vleggeert-Lankamp, Carmen, Baglin, Trevor, Volovici, Victor, Vulekovic, Peter, Vámos, Zoltán, Wade, Derick, Wang, Kevin K. W., Wang, Lei, Wildschut, Eno, Williams, Guy, Willumsen, Lisette, Wilson, Adam, Bartels, Ronald, Wilson, Lindsay, Winkler, Maren K. L., Ylén, Peter, Younsi, Alexander, Zaaroor, Menashe, Zhang, Zhiqun, Zheng, Zelong, Zumbo, Fabrizio, de Lange, Stefanie, de Ruiter, Godard C. W., Barzó, Pál, den Boogert, Hugo, van Dijck, Jeroen, van Essen, Thomas A., van Heugten, Caroline, van der Jagt, Mathieu, van der Naalt, Joukje, Beqiri, Erta, Bauerfeind, Ursula, Beer, Ronny, Belda, Francisco Javier, Bellander, Bo-Michael, Belli, Antonio, Bellier, Rémy, Benali, Habib, Benard, Thierry, Berardino, Maurizio, Beretta, Luigi, Beynon, Christopher, Bilotta, Federico, Binder, Harald, Blaabjerg, Morten, Borgen, Lund Stine, Bouzat, Pierre, Bragge, Peter, Brazinova, Alexandra, Brehar, Felix, Brorsson, Camilla, Buki, Andras, Bullinger, Monika, Buc̆ková, Veronika, Calappi, Emiliana, Cameron, Peter, Carbayo, Lozano Guillermo, Carise, Elsa, Carpenter, K., Castaño-León, Ana M., Causin, Francesco, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Cnossen, Maryse, Coburn, Mark, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Covic, Amra, Curry, Nicola, Czeiter, Endre, Czosnyka, Marek, Dahyot-Fizelier, Claire, Damas, François, Damas, Pierre, Dawes, Helen, De Keyser, Véronique, Della Corte, Francesco, Depreitere, Bart, Ding, Shenghao, Dippel, Diederik, Dizdarevic, Kemal, Dulière, Guy-Loup, Dzeko, Adelaida, Eapen, George, Engemann, Heiko, Ercole, Ari, Esser, Patrick, Ezer, Erzsébet, Fabricius, Martin, Feigin, Valery L., Feng, Junfeng, Foks, Kelly, Fossi, Francesca, Francony, Gilles, Frantzén, Janek, Public Health, Erasmus MC other, Zeiler, Frederick A [0000-0003-1737-0510], Maas, Andrew I R [0000-0003-1612-1264], Maas, Andrew IR [0000-0003-1612-1264], CENTER-TBI Investigators |
| Rok vydání: | 2021 |
| Předmět: |
Critical Care and Emergency Medicine
Traumatic Brain Injury Pooling Blood Pressure Logistic regression Vascular Medicine Outcome (game theory) Mathematical and Statistical Techniques Cognition Statistics Brain Injuries Traumatic Psychology Imputation (statistics) Hypoxia Trauma Medicine Neurologic Examination Multidisciplinary FOS: Social sciences Prognosis Physical sciences Medicine Hypotension Traumatic Injury Research Article medicine.medical_specialty Critical Care Traumatic brain injury Cognitive Neuroscience Resuscitation Science Decision Making FOS: Physical sciences Social sciences Motor Reactions Physical medicine and rehabilitation Covariate medicine Humans Glasgow Coma Scale Statistical Methods Baseline (configuration management) Medicine and health sciences Models Statistical Biology and life sciences business.industry Cognitive Psychology Cell Biology Emergency department medicine.disease Missing data Research and analysis methods Logistic Models Cognitive Science Human medicine business Neurotrauma Mathematics Neuroscience Forecasting |
| Zdroj: | PLOS ONE 16(8), e0253425 (2021). doi:10.1371/journal.pone.0253425 PLoS ONE, 16(8 August):e0253425. Public Library of Science PLoS ONE, Vol 16, Iss 8, p e0253425 (2021) PLoS ONE PLoS ONE, 16(8). PUBLIC LIBRARY SCIENCE |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0253425 |
| Popis: | Funder: One Mind for Research Funder: bill and melinda gates foundation (us) Funder: University of Manitoba VPRI Research investment fund Funder: Winniped Health Sciences Centre HSC Foundation Funder: ZNS - Hannelore Kohl Stiftung (DE) Funder: Integra LifeSciences (US) Funder: Rudy Falk Professorship Statistical models for outcome prediction are central to traumatic brain injury research and critical to baseline risk adjustment. Glasgow coma score (GCS) and pupil reactivity are crucial covariates in all such models but may be measured at multiple time points between the time of injury and hospital and are subject to a variable degree of unreliability and/or missingness. Imputation of missing data may be undertaken using full multiple imputation or by simple substitution of measurements from other time points. However, it is unknown which strategy is best or which time points are more predictive. We evaluated the pseudo-R2 of logistic regression models (dichotomous survival) and proportional odds models (Glasgow Outcome Score—extended) using different imputation strategies on the The Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study dataset. Substitution strategies were easy to implement, achieved low levels of missingness (<< 10%) and could outperform multiple imputation without the need for computationally costly calculations and pooling multiple final models. While model performance was sensitive to imputation strategy, this effect was small in absolute terms and clinical relevance. A strategy of using the emergency department discharge assessments and working back in time when these were missing generally performed well. Full multiple imputation had the advantage of preserving time-dependence in the models: the pre-hospital assessments were found to be relatively unreliable predictors of survival or outcome. The predictive performance of later assessments was model-dependent. In conclusion, simple substitution strategies for imputing baseline GCS and pupil response can perform well and may be a simple alternative to full multiple imputation in many cases. |
| Databáze: | OpenAIRE |
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