Prevalence and progression of cardiovascular calcifications in peritoneal dialysis patients: A prospective study
| Autor: | Gallieni M, Caputo F, Filippini A, Gabella P, Giannattasio M, Stingone A, Farina M, Amato M, Avella F, Bertoli M, Bocci C, Borgatti P, Buongiorno E, Cavatorta F, Cabiddu G, Coratelli P, Costanzo R, Daidone G, D'Angelo A, Della Grotta F, De Vecchi A, Ferrari G, Gaggiotti E, Fanciulli E, Fusaroli M, La Rosa R, Malberti F, Marinangeli G, Mauro MM, Oliva B, Orazi E, Rapisarda F, Rocca AR, Ronco C, Sacchetti A, Sasdelli M, Scanziani R, Sessa A, Spinelli C, STEFONI, SERGIO, Viglino G. |
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| Přispěvatelé: | Gallieni M, Caputo F, Filippini A, Gabella P, Giannattasio M, Stingone A, Farina M, Amato M, Avella F, Bertoli M, Bocci C, Borgatti P, Buongiorno E, Cavatorta F, Cabiddu G, Coratelli P, Costanzo R, Daidone G, D'Angelo A, Della Grotta F, De Vecchi A, Ferrari G, Gaggiotti E, Fanciulli E, Fusaroli M, La Rosa R, Malberti F, Marinangeli G, Mauro MM, Oliva B, Orazi E, Rapisarda F, Rocca AR, Ronco C, Sacchetti A, Sasdelli M, Scanziani R, Sessa A, Spinelli C, Stefoni S, Viglino G. |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Histology Physiology Endocrinology Diabetes and Metabolism medicine.medical_treatment Population Left ventricular hypertrophy Gastroenterology Peritoneal dialysis Young Adult Cardiovascular calcification PERITONEAL DIALYSIS Internal medicine medicine Prevalence CKD-MBD Humans Renal osteodystrophy Prospective Studies education Prospective cohort study Dialysis CARDIOVASCULAR CALCIFICATION Aged Demography Aged 80 and over education.field_of_study business.industry Calcinosis Phosphorus Middle Aged medicine.disease Survival Analysis Surgery Italy Multivariate Analysis OBSERVATIONAL STUDY Disease Progression SURVIVAL Calcium Female Hypertrophy Left Ventricular Hemodialysis business Cardiomyopathies |
| Popis: | Background Patients on dialysis may have abnormal serum levels of Ca, P and parathyroid hormone, with related bone diseases. This population has an increased risk of death, with cardiovascular calcification (CC) a contributing factor. Patients on peritoneal dialysis appear to be at increased risk of hyperlipidemia, a contributing factor to atherosclerotic plaque formation. Although several studies have described the presence and progression of CC in hemodialysis populations, there are fewer data in patients on peritoneal dialysis. Study design The Renal Osteodystrophy and Calcifications: Key factors in Peritoneal Dialysis (ROCK-PD) study was a 36-month, prospective observational study conducted in Italy. The study examined the presence and progression of CC in two cardiac valves and five arterial sites. The potential associations of serum Ca and P with mortality and cardiovascular morbidity, demographic, clinical and blood chemistry variables was investigated. Results CC was present in 77% of patients at baseline ( N = 369) and in 90% of patients by study end ( N = 145), progressing in 73% of patients. There were 42 deaths (11%). Analyses showed a marked correlation between baseline P levels and the presence of left ventricular hypertrophy. However, there were no consistent correlations between serum Ca or P with mortality or morbidity. Conclusions CC was common in peritoneal dialysis patients and progressed in a majority of patients. |
| Databáze: | OpenAIRE |
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