The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma: correlation to overall survival
| Autor: | Birgitta Sander, A. Charlotta Asplund, Anna Porwit, Birger Christensson, Jenny Flygare, C. I. Edvard Smith, Xiao Wang |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Cytoplasm medicine.medical_specialty Pathology Follicular lymphoma Gene Expression Kaplan-Meier Estimate Lymphoma Mantle-Cell Biology SOXC Transcription Factors immune system diseases hemic and lymphatic diseases Internal medicine Gene expression Biomarkers Tumor medicine Humans Cyclin D1 neoplasms Transcription factor Aged Aged 80 and over Cell Nucleus Hematology Cell growth Cancer Middle Aged medicine.disease Immunohistochemistry Gene Expression Regulation Neoplastic Survival Rate Lymphatic system Cancer research Female Mantle cell lymphoma |
| Zdroj: | British Journal of Haematology. 143:248-252 |
| ISSN: | 1365-2141 0007-1048 |
| Popis: | Summary Gene expression analysis demonstrated high expression of the neuronal transcription factor SOX11 in mantle cell lymphoma (MCL). In contrast to follicular lymphoma, small lymphocytic lymphoma and reactive lymphoid tissue, most MCLs tested (48/53 patients) expressed sox11 protein in the nucleus. Therefore nuclear sox11 expression represents a new tumour marker for a subset of MCL. However, 5/53 MCL cases expressed sox11 only in the cytoplasm; these MCL patients had a shorter survival compared to MCL with nuclear sox11 expression. These results suggest sox11 expression as a new diagnostic marker in MCL that could be related to the clinical and biological behaviour of MCL. |
| Databáze: | OpenAIRE |
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