Executive dysfunction in medicated, remitted state of major depression
| Autor: | Hitoshi Maeshima, Kanako Baba, Yoshie Sakai, Akiyoshi Kitajima, Toshihito Suzuki, Hajime Baba, Masaru Mimura, Yoshiyuki Nakano, Heii Arai |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Neuropsychological Tests behavioral disciplines and activities Wisconsin Card Sorting Test mental disorders medicine Verbal fluency test Humans Psychiatry Aged Depressive Disorder Major Dementia Vascular Cognitive disorder Neuropsychology Middle Aged medicine.disease Executive functions Control Groups Frontal Lobe Hospitalization Psychiatry and Mental health Clinical Psychology Cerebrovascular Disorders Treatment Outcome Major depressive disorder Regression Analysis Female Psychology Cognition Disorders Stroop effect Executive dysfunction Clinical psychology |
| Zdroj: | Journal of affective disorders. 111(1) |
| ISSN: | 0165-0327 |
| Popis: | Background Past neuropsychological studies on depression have documented executive dysfunction and it has been reported that some dysfunction persists even after depressive symptoms disappear. Studies have shown a correlation between cerebrovascular lesions and executive dysfunction in depression among the elderly. The aim of the present study was to focus on executive functions in remitted major depressive disorder (MDD) patients, and to investigate whether remitted young and elderly patients show different patterns of executive dysfunction, and to ascertain the relationships with vascular lesions. Methods Subjects were 79 inpatients with MDD and 85 healthy controls. Each subject received Wisconsin Card Sorting Test (WCST), Stroop test, and Verbal Fluency Test (VFT) in a remitted state. Both the MDD and control groups were divided into young and elderly groups, and the performances between 4 groups were compared. Results For Stroop test, the scores of the MDD group were significantly lower than controls. In addition, as for VFT, the scores for the elderly MDD group were significantly lower than the other groups. Multiple regression analysis showed that VFT scores were affected by the presence of vascular lesions. Conclusions The results of the present study demonstrated that executive dysfunction remained even in a remitted state in MDD patients, but the patterns of impairment were different between young and elderly patients. The results also suggested that vascular lesions affect executive dysfunction, particularly in elderly depressive patients. |
| Databáze: | OpenAIRE |
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