Comparison of Tc-99m MDP, Tc-99m HSA and Tc-99m HIG uptake in rheumatoid arthritis and its variants
Autor: | İrem Bernay, Tarik Basoglu, Ferhan Cantürk, Murathan Sahin |
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Přispěvatelé: | Ondokuz Mayıs Üniversitesi |
Rok vydání: | 1999 |
Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty Pathology Adolescent Metabolic Clearance Rate technetium-99m methylene diphosphonate Immunoglobulins Arthritis chemistry.chemical_element Technetium Tc 99m Aggregated Albumin Technetium Tc 99m Medronate Wrist Technetium Gastroenterology technetium-99m polyclonal immunoglobulin G Isotopes of technetium Arthritis Rheumatoid Vascularity Technetium-99 Internal medicine Humans Medicine Radiology Nuclear Medicine and imaging Radionuclide Imaging technetium-99m albumin business.industry General Medicine Middle Aged medicine.disease body regions medicine.anatomical_structure arthritis chemistry Rheumatoid arthritis Female Joints Radiopharmaceuticals medicine.symptom business |
Zdroj: | Annals of Nuclear Medicine. 13:389-395 |
ISSN: | 1864-6433 0914-7187 0000-8478 |
Popis: | WOS: 000084782900004 PubMed: 10656272 Tc-99m polyclonal immunoglobulin-a has been shown to be a successful agent in the depiction of active inflammation in rheumatoid arthritis (RA). The objective of this study was to compare the uptake behaviors of Tc-99m HIG and Tc-99m MDP in RA and variants of rheumatoid arthritis (VRA). Seventeen patients with RA and 8 patients with VRA presenting with active inflammation were included in this study. Ten subjects with well-diagnosed degenerative joint disease constituted the control group. All joints in patients were also imaged with Tc-99m HSA to evaluate the vascularization status of the joints. Tc-99m HIG and HSA scans were obtained at 2, 4 and 24 hours after the injection of 555 MBq Tc-99m HIG and 296 MBq Tc-99m HSA. Conventional bone scans were performed 4 hours after the injection of 740 MBq Tc-99m MDP. Target-to-background (T/B) ratios were obtained exclusively over the joint regions. Tc-99m HIG T/B ratios of the active joints in RA were significantly higher than those of the non-active joints and the control group (p < 0.05). Tc-99m HIG T/B ratios in active joints showed a progressive increase between 2 and 24 hour images (p < 0.05). In contrast, Tc-99m HSA TIE ratios decreased in all active joints significantly (p < 0.05) except the ankle joint region (p > 0.05). The T/B ratios in Tc-99m MDP bone scans were higher in all active joints than in non-active RA joints and joints of controls but significantly differences were only detected in wrist and elbow joints. All clinically active joints in VRA patients accumulated Tc-99m HIG and HSA, and showed increased Tc-99m MDP uptake. These joints had a very similar Tc-99m HIG retention pattern to the RA joints. The detection rate of active joint inflammation with Tc-99m HIG was much higher than that with Tc-99m MDP. The increasing Tc-99m HIG uptake ratio between 2 and 24 hours in contrast to Tc-99m HSA indicates the presence of other binding mechanisms besides increased vascularity in RA. |
Databáze: | OpenAIRE |
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