Early Pregnancy Maternal Hepatocyte Growth Factor and Risk of Gestational Diabetes
| Autor: | Michelle A. Williams, Daniel A. Enquobahrie, Neway G. Fida, Chunfang Qiu, Karin Hevner, Michal Dishi, Dejene F. Abetew |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
2. Zero hunger
Hepatocyte growth factor Pregnancy medicine.medical_specialty obesity Environmental Engineering business.industry Obstetrics Case-control study nutritional and metabolic diseases physical activity Overweight medicine.disease Obesity Industrial and Manufacturing Engineering Article gestational diabetes mellitus 3. Good health Gestational diabetes Blood serum Diabetes mellitus medicine Gestation medicine.symptom business |
| Zdroj: | British journal of medicine and medical research |
| ISSN: | 2231-0614 |
| Popis: | AIMS We investigated associations of serum hepatocyte growth factor (HGF) with risk of gestational diabetes mellitus (GDM). We also examined whether pre-pregnancy overweight/obesity status or leisure-time physical activity (LTPA) modify these associations. METHODS In a nested case-control study (173 GDM cases and 187 controls) among participants of a pregnancy cohort, early pregnancy (16 weeks of gestation, on average) serum HGF was measured using enzyme-linked immunoassay. GDM was diagnosed using American Diabetes Association guidelines. Logistic regression was used to calculate odd ratios (ORs) and 95% confidence intervals (CI). Effect modifications by pre-pregnancy overweight/obesity status or LTPA during pregnancy were examined using stratified analyses and interaction terms. RESULTS Overall, we did not find significant associations of serum HGF with GDM risk (p-value> 0.05). However, compared with women who had low serum HGF concentrations ( |
| Databáze: | OpenAIRE |
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