Lipid Peroxidation as a Marker of Apathy and Executive Dysfunction in Patients at Risk for Vascular Cognitive Impairment

Autor:	Kritleen K, Bawa, Joycelyn, Ba, Alex, Kiss, RuoDing, Wang, Vivian, Feng, Walter, Swardfager, Ana, Andreazza, Damien, Gallagher, Giovanni, Marotta, Nathan, Herrmann, Krista L, Lanctôt
Rok vydání:	2022
Předmět:	Executive Function Lipid Peroxides Psychiatry and Mental health Clinical Psychology General Neuroscience Apathy Humans Cognitive Dysfunction Lipid Peroxidation General Medicine Neuropsychological Tests Geriatrics and Gerontology Biomarkers
Zdroj:	Journal of Alzheimer's Disease. 89:733-743
ISSN:	1875-8908 1387-2877
DOI:	10.3233/jad-220274
Popis:	Background: The co-occurrence of apathy and executive dysfunction, a correlate of vascular cognitive impairment (VCI), is highly prevalent, yet facilitating factors are largely unknown. Objective: This study investigates the relationship between lipid peroxidation, apathy, and executive dysfunction in patients at risk for VCI. Methods: In participants with coronary artery disease, who are at a high risk of VCI, apathy (Apathy Evaluation Scale), and executive function (composite z-score based on age and education population norms from trails making test B, animal naming, and phonemic fluency tests) were assessed. Serum concentrations of an early (lipid hydroperoxide (LPH)) and late (8-isoprostane (8-ISO)) lipid peroxidation marker, were measured and the 8-ISO/LPH ratio was calculated. Results: Participants (n = 206, age±SD = 63.0±7.5, 80% men, total years of education = 15.9±3.4, AES score = 28.3±8.8, executive function = 0±1) demonstrated significantly different 8-ISO/LPH ratios between groups (F(3, 202) = 10.915, p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ecda2c6d306e5eef1712f2dade27b2a https://doi.org/10.3233/jad-220274 Zobrazit plný text záznamu