Neural signatures of autism
| Autor: | Su Mei Lee, Allison M Berken, Ben Deen, Martha D. Kaiser, Kevin A. Pelphrey, Avery C. Voos, Ami Klin, Pamela Ventola, Celine Saulnier, Naomi B. Pitskel, Celeste H. M. Cheung, Brent C. Vander Wyk, Caitlin M. Hudac, Julie M. Wolf, Sarah Shultz, Daniel R Sugrue |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Neurons
Multidisciplinary medicine.diagnostic_test Mechanism (biology) Movement Siblings Biological Sciences medicine.disease Magnetic Resonance Imaging Child Development Disorders Pervasive Autism spectrum disorder Endophenotype mental disorders medicine Trait Humans Autism Autistic Disorder Genetic risk Child Functional magnetic resonance imaging Psychology Neuroscience Biological motion |
| Zdroj: | Proceedings of the National Academy of Sciences. 107:21223-21228 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.1010412107 |
| Popis: | Functional magnetic resonance imaging of brain responses to biological motion in children with autism spectrum disorder (ASD), unaffected siblings (US) of children with ASD, and typically developing (TD) children has revealed three types of neural signatures: ( i ) state activity, related to the state of having ASD that characterizes the nature of disruption in brain circuitry; ( ii ) trait activity, reflecting shared areas of dysfunction in US and children with ASD, thereby providing a promising neuroendophenotype to facilitate efforts to bridge genomic complexity and disorder heterogeneity; and ( iii ) compensatory activity, unique to US, suggesting a neural system–level mechanism by which US might compensate for an increased genetic risk for developing ASD. The distinct brain responses to biological motion exhibited by TD children and US are striking given the identical behavioral profile of these two groups. These findings offer far-reaching implications for our understanding of the neural systems underlying autism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|