Emerging roles of orphan nuclear receptors in regulation of innate immunity
| Autor: | Tae Sung Kim, Eun-Kyeong Jo, Hyo Sun Jin |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
First line Pharmacology toxicology Inflammation Biology Ligands 03 medical and health sciences Drug Discovery medicine Animals Humans Transcription factor Innate immune system Organic Chemistry Bacterial Infections Orphan Nuclear Receptors humanities Physiological responses Immunity Innate 030104 developmental biology Nuclear receptor Immunology Molecular Medicine medicine.symptom human activities Protein Processing Post-Translational Signal Transduction |
| Zdroj: | Archives of pharmacal research. 39(11) |
| ISSN: | 1976-3786 |
| Popis: | Innate immunity constitutes the first line of defense against pathogenic and dangerous insults. However, it is a double-edged sword, as it functions in both clearance of infection and inflammatory damage. It is therefore important that innate immune responses are tightly controlled to prevent harmful excessive inflammation. Nuclear receptors (NRs) are a family of transcription factors that play critical roles in various physiological responses. Orphan NRs are a subset of NRs for which the ligands and functions are unclear. Accumulating evidence has revealed that orphan NRs play essential roles in innate immune responses to prevent pathogenic inflammatory responses and to enhance antimicrobial host defenses. In this review, we describe current knowledge on the roles and mechanisms of orphan NRs in the regulation of innate immune responses. Discovery of new functions of orphan NRs would facilitate development of novel preventive and therapeutic strategies against human inflammatory diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink