Chronic granulomatous inflammation of the breast as a first clinical manifestation of primary sarcoidosis
| Autor: | Lara Valenčić, Petra Valković Zujić, Damir Grebić |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Systemic disease
medicine.medical_specialty medicine.diagnostic_test business.industry Physical examination medicine.disease Malignancy Breast cancer Oncology Novel Insights from Clinical Practice Biopsy medicine Mammography Surgery Radiology Sarcoidosis Differential diagnosis business breast sarcoidosis core needle biopsy granulomatous disease |
| DOI: | 10.1159/000370206 |
| Popis: | Background: Sarcoidosis is an idiopathic multisystemic disease that affects young to middle aged adults, with higher incidence in women. Although it may involve the breast parenchyma, primary sarcoidosis of the breast is very rare. It occurs in less than 1% of cases. In a differential diagnosis it may potentially be considered a malignancy. Case Report: We report a case in which breast sarcoidosis was the first clinical manifestation of systemic disease in a 54-year-old woman who presented with wide erythematous skin changes associated with palpable induration. Considering the fact that physical examination and the results of mammography, ultrasound and magnetic resonance imaging were inconclusive and unable to rule out malignancy, biopsy was performed. Pathohistological diagnosis showed a non-necrotizing granulomatous inflammation without elements of breast cancer. Sarcoidosis was confirmed with elevated level of angiotensin-converting enzyme in the sera and characteristic chest multislice computed tomography findings. The bronchoalveolar lavage was infiltrated with lymphocytes. Conclusion: Breast sarcoidosis has diverse and nonspecific imaging characteristics. Carcinoma must always be excluded by core needle biopsy. Achieving correct diagnosis is mandatory so that adequate corticosteroid therapy can be applied as early as possible. A multidisciplinary approach is of utmost importance in the diagnostic workup. |
| Databáze: | OpenAIRE |
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