Plasma free 5-hydroxytryptamine (5-HT): Evidence of an increase induced by LM 5008, a potent 5-HT uptake inhibitor
| Autor: | N. Mitrani, Andre Uzan, Marie Kabouche, G. Le Fur |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Blood Platelets
Male Serotonin medicine.medical_specialty Indoles Synaptic cleft General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Urinary excretion 5 ht uptake Piperidines Oral administration Internal medicine medicine Animals Platelet General Pharmacology Toxicology and Pharmaceutics Neurotransmitter 5-HT receptor Chemistry Biological Transport General Medicine Metabolism Hydroxyindoleacetic Acid Rats Kinetics Endocrinology |
| Zdroj: | Life Sciences. 23:1317-1324 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(78)90389-2 |
| Popis: | When 5-HT platelet uptake was inhibited in rats by single or repeated oral administration of 4-[2-(3-indolyl)ethyl]piperidine (LM 5008), 5-hydroxy-indole-acetic acid (5-HIAA) and 5-HT platelet concentration decreased. An oral administration of LM 5008 (10 mg/kg) to rats whose platelets were previously labeled with tritiated 5-HT provoked an increase in plasma free 5-HT and 5-HIAA. The maximum rise in 5-HT occured at 15 min while that of 5-HIAA appeared later (30 min). Concurrently urinary excretion of 5-HT was dramatically increased (about 5 times the control value) which indicates that 5-HT metabolism was not stimulated. According to the similarity between blood platelets and tryptaminergic neurons, plasma free 5-HT variations appeat to reflect changes of the neurotransmitter level into the synaptic cleft. Moreover, the excess of plasma free 5-HT induced by LM 5008 could improve 5-HT effects on vascular tone and pain. |
| Databáze: | OpenAIRE |
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