Adriamycin-related anxiety-like behavior, brain oxidative stress and myelotoxicity in male Wistar rats
| Autor: | Abdelkrim Tahraoui, Sameha Merzoug, Bruno Baudin, Nadia Boukhris, Mohamed Lamine Toumi |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_treatment Lymphocyte Clinical Biochemistry Intraperitoneal injection Nerve Tissue Proteins Granulocyte Pharmacology Anxiety Motor Activity Toxicology medicine.disease_cause Weight Gain Biochemistry Open field Behavioral Neuroscience chemistry.chemical_compound Bone Marrow Medicine Animals Rats Wistar Biological Psychiatry Glutathione Transferase Brain Chemistry Antibiotics Antineoplastic business.industry Monocyte Glutathione Malondialdehyde Blood Cell Count Rats Oxidative Stress medicine.anatomical_structure chemistry Doxorubicin Immunology Lipid Peroxidation business Oxidative stress |
| Zdroj: | Pharmacology, biochemistry, and behavior. 99(4) |
| ISSN: | 1873-5177 |
| Popis: | Chemotherapeutic regimens have been indicated to negatively impact the quality of life for patients. Adriamycin (ADR) is an effective chemotherapeutic agent widely employed for the treatment of human's malignancies; however, it may cause serious side effects. The present study was aimed at investigating the effects of acute administration of ADR on cognitive alterations, brain oxidative status and immune dysregulation in male Wistar rats. Treated animals received a single intraperitoneal injection of ADR (7 mg/kg). Control ones received physiological saline only. Behavioral effects were tested in the elevated plus-maze and the open field which showed that drug-treated rats displayed anxious behavior and deteriorations in the locomotive and exploratory activities over the 72 h following ADR injection as compared to controls. Assessment of brain antioxidant capacity in ADR-injected animals revealed an increase in glutathione-S-transferase activities and malondialdehyde levels while a decrease in glutathione concentrations when compared with the vehicle-treated group. Our results indicated that ADR administration decreased total leukocyte, lymphocyte and granulocyte counts, while enhanced monocyte levels. Moreover, white blood cells (WBC) relative counts in ADR-treated rats showed a significant increase in monocytes and granulocytes and a decrease in lymphocytes as compared to controls. This study suggests that ADR-related cognitive impairments are associated with brain oxidative stress and myelosuppression. |
| Databáze: | OpenAIRE |
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