A case report of carfentanil-related fatality in France
| Autor: | Camille Richeval, Véronique Dumestre-Toulet, Sandrine Brault, Mélodie Phanithavong, Delphine Allorge, Jean-Michel Gaulier |
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| Přispěvatelé: | Impact de l'environnement chimique sur la santé humaine - ULR 4483 (IMPECS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille) |
| Rok vydání: | 2019 |
| Předmět: |
business.industry
[SDV]Life Sciences [q-bio] Health Toxicology and Mutagenesis Metabolite 010401 analytical chemistry Context (language use) Urine Toxicology 01 natural sciences Sudden death 3. Good health 0104 chemical sciences Fentanyl Carfentanil 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Anesthesia Medicine Medical history 030216 legal & forensic medicine business Syringe medicine.drug |
| Zdroj: | Toxicologie Analytique et Clinique Toxicologie Analytique et Clinique, 2019, 31, pp.323-331. ⟨10.1016/j.toxac.2019.01.002⟩ Toxicologie Analytique et Clinique, Elsevier, 2019, 31, pp.323-331. ⟨10.1016/j.toxac.2019.01.002⟩ |
| ISSN: | 2352-0078 |
| Popis: | Summary Today, NPS are increasingly being related to post-mortem cases, and this problem drastically intensifies as a result of the New Synthetic Opioids (NSOs) surge. Among NSOs, carfentanil (CaF) is the most potent fentanyl analogue and was central to a large number of NSOs-related fatalities in North America, as well as in UE, since 2016. In this worrisome context, this manuscript reports the first CaF-related fatality occurred in France. A 41-years-old man was found dead with a syringe planted under his tongue. This man has a psychiatric follow-up for opiate addiction and his recent medical history included intoxication with fentanyl derivatives. Toxicological investigations of post-mortem samples (blood, urine and hair), and syringe were requested. CaF (with several other psychoactive drugs at non-toxic level) was detected in biological samples and in syringe residue using LC-HRMS, and quantified using LC-MS/MS in blood, urine and hair (from proximal to distal hair section – 3 cm length each) at 4.20, 0.40 μg/L and 54/114/166 pg/mg, respectively. The relatively high post-mortem CaF blood concentration together with the absence of metabolite (especially NorCaF) suggests a sudden death of the victim immediately following a significant CaF dose intake (presumably injected) that can explain the decease. |
| Databáze: | OpenAIRE |
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