Potential Role for Growth Hormone in Human Lactation Insufficiency
| Autor: | Alistair J. Gunn, Stella R. Milsom, Peter D. Gluckman, Diana L. Rabone |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Lactation Disorders Growth hormone Endocrinology Lactation Internal medicine Humans Medicine Single-Blind Method Dose-Response Relationship Drug Human Growth Hormone business.industry Recombinant Proteins Circadian Rhythm Treatment Outcome medicine.anatomical_structure Pediatrics Perinatology and Child Health Female business Breast feeding Early postpartum |
| Zdroj: | Hormone Research in Paediatrics. 50:147-150 |
| ISSN: | 1663-2826 1663-2818 |
| DOI: | 10.1159/000023263 |
| Popis: | In order to evaluate the galactopoietic response to rhGH in mothers of normal babies with idiopathic lactation insufficiency arising in the early postpartum period, we performed a preliminary, randomised, single blind trial of 3 different doses of hGH: either 0.05, 0.1, or 0.2 IU/kg/day to a maximum of 16 IU/day, for 7 days. Total 24-hour milk production was determined in each mother 1 day prior to initiating therapy and on the last day of therapy. Milk production rose by 36.0 ± 12.6% in the group receiving 0.2 IU/kg/day (n = 6) but by only 4.7 ± 9.7%, (p < 0.04) in the combined lower dose group (n = 10). In conclusion, these data suggest that moderate dose hGH therapy in mothers with lactation insufficiency can improve galactopoiesis. |
| Databáze: | OpenAIRE |
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