Untangling a Web: Basic Mechanisms of the Complex Interactions Between Sleep, Circadian Rhythms, and Epilepsy
| Autor: | Rama Maganti, Mathew V. Jones |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Exacerbating factor
Exacerbation business.industry Disease progression sleep and circadian medicine.disease Sleep in non-human animals Current Review in Basic Science Sleep deprivation Epilepsy medicine epilepsy Neurology (clinical) Circadian rhythm medicine.symptom business neuronal excitability Transcription factor Neuroscience seizures |
| Zdroj: | Epilepsy Currents |
| ISSN: | 1535-7511 1535-7597 |
| Popis: | Seizures have sleep–wake and circadian patterns in various epilepsies and, in turn, disrupt sleep and circadian rhythms. The resultant sleep deprivation (SD) is an exacerbating factor for seizures that sets up a vicious cycle that can potentially lead to disease progression and even to epilepsy-related mortality. A variety of cellular or network electrophysiological changes and changes in expression of clock-controlled genes or other transcription factors underlie sleep–wake and circadian distribution of seizures, as well as the disruptions seen in both. A broad understanding of these mechanisms may help in designing better treatments to prevent SD-induced seizure exacerbation, disrupt the vicious cycle of disease progression, and reduce epilepsy-related mortality. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |