Surveillance MRI for the detection of locally recurrent Ewing sarcoma seems futile
| Autor: | Amelie Dammann, Rudi Dierckx, Jelle Overbosch, Ömer Kasalak, Hugo J. A. Adams, Paul C Jutte, Thomas C. Kwee |
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| Přispěvatelé: | Molecular Neuroscience and Ageing Research (MOLAR), Public Health Research (PHR), Man, Biomaterials and Microbes (MBM), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Radiology and Nuclear Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Survival Contrast Media Bone Neoplasms Gadolinium Disease Newly diagnosed Sarcoma Ewing 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Meglumine Recurrence Recurrent Ewing Sarcoma Overall survival medicine Recurrent disease Organometallic Compounds Humans Radiology Nuclear Medicine and imaging DEPOSITION Child Retrospective Studies business.industry Middle Aged medicine.disease Primary tumor Magnetic Resonance Imaging Survival Rate 030220 oncology & carcinogenesis Child Preschool Orthopedic surgery Female Radiology Sarcoma Neoplasm Recurrence Local business Ewing sarcoma MRI |
| Zdroj: | Skeletal Radiology, 47(11), 1517-1522. SPRINGER Skeletal radiology, 47(11), 1517-1522. Springer Verlag |
| ISSN: | 0364-2348 |
| Popis: | PURPOSE: To determine the frequency of locally recurrent Ewing sarcoma on surveillance MRI and the outcome of these patients.MATERIALS AND METHODS: This retrospective single-center study included all patients with newly diagnosed Ewing sarcoma who underwent surveillance MRI of the primary tumor location after primary treatment between 1997 and 2016.RESULTS: Thirty-two patients underwent a total of 176 local surveillance MRI scans, yielding an average of 5.5 ± 4.4 MRI scans per patient. Follow-up time of surveillance MRI after completion of primary treatment ranged between 1 and 111 months. Surveillance MRI detected five (15.6%) locally recurrent Ewing sarcomas, at 2, 4, 6, 6, and 7 months after completion of primary treatment, of whom three also had simultaneous recurrent (metastatic) disease elsewhere. Two patients had recurrent metastatic disease without any signs of locally recurrent disease on surveillance MRI. All five patients with locally recurrent disease on surveillance MRI died, at 2, 4, 5, 8, and 9 months after local recurrence detection. Patients with locally recurrent disease had a significantly worse overall survival than patients without locally recurrent disease (log-rank test, P CONCLUSIONS: A limited number of patients have locally recurrent Ewing sarcoma on surveillance MRI. These patients often have simultaneous recurrent (metastatic) disease elsewhere, and their outcome is poor. Moreover, some patients present without locally recurrent disease on MRI but disease recurrence elsewhere. Therefore, surveillance MRI currently seems to have little value and should be reconsidered, also given the costs and the repeated exposure of surviving patients to gadolinium-based contrast agents. |
| Databáze: | OpenAIRE |
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