Spray dried nanoemulsions loaded with curcumin, resveratrol, and borage seed oil: The role of two different modified starches as encapsulating materials
Autor: | Bilal Sajid Mushtaq, Qunyi Tong, Saadia Zainab, Abdur Rehman, Seid Mahdi Jafari, Sameh A. Korma, Muhammad Faisal Manzoor, Ilaria Cacciotti, Ali Mohsin, Imran Mahmood Khan, Waqas Ashraf |
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Rok vydání: | 2021 |
Předmět: |
Curcumin
Time Factors Antioxidant Water activity Scanning electron microscope Drug Compounding Drug Storage medicine.medical_treatment Biochemistry Antioxidants chemistry.chemical_compound Drug Stability Structural Biology medicine Nanotechnology Plant Oils gamma-Linolenic Acid Molecular Biology Dissolution Drug Carriers Moisture Chemistry Succinic anhydride Spray Drying Starch General Medicine medicine.drug_formulation_ingredient Resveratrol Nanoparticles Borage seed oil Emulsions Powders Oxidation-Reduction Nuclear chemistry |
Zdroj: | International Journal of Biological Macromolecules. 186:820-828 |
ISSN: | 0141-8130 |
DOI: | 10.1016/j.ijbiomac.2021.07.076 |
Popis: | Recently, food industries are directing on the promotion of innovative food matrices fortified with bioactive compounds in order to enhance the consumer's health. Octenyl succinic anhydride modified starches (OSA-MS) such as Hi-cap100 (HCP) and purity gum 2000 (PUG) were used to fabricate emulsions co-entrapped with borage seed oil (BSO), resveratrol (RES) and curcumin (CUR), which were further spray dried to obtain powders. The fabricated microcapsules loaded with BSO, RES, and CUR displayed excellent dissolution performance, high encapsulation efficiency (≈93.05%) as well as semi-spherical shape, revealed via scanning electron microscopy (SEM). We also evaluated the impact of storage time (4 weeks) and temperature (40 °C) on the physicochemical characterization of OSA-MS coated microcapsules. Microcapsules coated with HCP exhibited greater oxidative stability, lower water activity and moisture contents rather than PUG coated microcapsules during storage because of its good film-forming properties. Addition of CUR enhanced the oxidative stability and retention of bioactive compounds. HCP microcapsules loaded with BSO + RES + CUR presented supreme retention of RES (70.32%), CUR 81.6% and γ-linolenic acid (≈ 96%). Our findings showed that CUR acted as an antioxidant agent; also, lower molecular weight OSA-MS as wall material could be used for the entrapment of bioactive compounds and promotion of innovative food products. |
Databáze: | OpenAIRE |
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