CD38 expression on gluten-specific T cells is a robust marker of gluten re-exposure in coeliac disease
| Autor: | Knut Ea Lundin, Ludvig M. Sollid, Asbjørn Christophersen, Louise Fremgaard Risnes, Stephanie Zühlke, Shiva Dahal-Koirala |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Glutens T-Lymphocytes Gene Expression CD38 digestive system Coeliac disease Antibodies 03 medical and health sciences Young Adult 0302 clinical medicine HLA Antigens medicine Humans Aged chemistry.chemical_classification Membrane Glycoproteins business.industry fungi Gastroenterology nutritional and metabolic diseases Treatment options Interleukin Middle Aged medicine.disease Gluten ADP-ribosyl Cyclase 1 digestive system diseases Chronic disorders Small intestine Immunoglobulin A Cd38 expression Celiac Disease medicine.anatomical_structure Oncology chemistry 030220 oncology & carcinogenesis Immunoglobulin G Immunology Cytokines 030211 gastroenterology & hepatology Female business Biomarkers Protein Binding |
| Zdroj: | United European gastroenterology journal. 7(10) |
| ISSN: | 2050-6414 |
| Popis: | Increasing efforts are being put into new treatment options for coeliac disease (CeD), a chronic disorder of the small intestine induced by gluten. Interleukin-2 (IL-2) and gluten-specific CD4 + T cells increase in the blood after four hours and six days, respectively, following a gluten challenge in CeD patients. These responses are unique to CeD and are not seen in controls. We aimed to evaluate different markers reflecting a recall response to gluten exposure that may be used to monitor therapy.CeD patients on a gluten-free diet underwent a one- (The frequency of gut-homing, tetramer-binding, CD4 + effector memory T (tetramer + β7 + TThe optimal time points for monitoring therapy response in CeD after a three-day oral gluten challenge is four hours for plasma IL-2 or six to eight days for the frequency of tetramer + β7 + T |
| Databáze: | OpenAIRE |
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